{"id":"W2741263093","doi":"10.1128/aem.01148-17","title":"Repression of Salmonella Host Cell Invasion by Aromatic Small Molecules from the Human Fecal Metabolome","year":2017,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Ministério da Ciência, Tecnologia e Inovação; Government of Canada","keywords":"Metabolome; Human feces; Salmonella; Host (biology); Feces; Biology; Psychological repression; Enterobacteriaceae; Microbiology; Computational biology; Bacteria; Metabolomics; Chemistry; Genetics; Escherichia coli; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007406592,0.0003742675,0.000214613,0.0002924569,0.0001035383,0.0002022418,0.00005497948,0.0001693219,0.001222677],"category_scores_gemma":[0.000143821,0.00008594416,0.0002542335,0.0002082767,0.0001175931,0.00007235839,0.0001939613,0.000247477,0.0002807991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009900345,"about_ca_system_score_gemma":0.0001423655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388726,"about_ca_topic_score_gemma":0.0007349793,"domain_scores_codex":[0.9999379,0.00001511484,0.000004255245,0.00001314789,0.00001399911,0.00001561693],"domain_scores_gemma":[0.9999281,0.00001865077,0.00001731809,0.00000561751,0.00001515395,0.00001522956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806803,0.00001568913,0.0005018893,0.00004664457,0.000008377751,0.00003150882,0.000005719202,0.00003822951,0.9976861,0.00000878387,0.00003149668,0.001344861],"study_design_scores_gemma":[0.00002957244,0.0006458537,0.02788555,0.00001837039,0.00003999083,0.000171532,0.00004944712,0.0006796079,0.9683735,0.00003468736,0.002063222,0.000008743982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919818,0.003116861,0.002339614,0.0001561645,0.00004331271,0.00002889839,0.001713277,0.0000384422,0.0005815783],"genre_scores_gemma":[0.9937063,0.001225355,0.001900025,0.00009652947,0.00001821004,0.00002428627,0.001904545,0.00001233593,0.001112398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222677,"threshold_uncertainty_score":0.00409025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007671650815823966,"score_gpt":0.2031355308638236,"score_spread":0.1954638800479996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}