{"id":"W2741422412","doi":"10.1158/1538-7445.am2017-1184","title":"Abstract 1184: Characterization of novel STAT5 inhibitors to interfere with the oncogenic activities of STAT5 in hematopoietic diseases","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"STAT5; Cancer research; Myeloid leukemia; Tyrosine kinase; Biology; Chemistry; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537716,0.00008695475,0.000230579,0.0002061458,0.0001224875,0.0000402387,0.0001890053,0.00002995855,0.000167922],"category_scores_gemma":[0.0001454608,0.00005611072,0.00004938143,0.000165794,0.000252569,0.0001614468,0.00008921122,0.0002841636,0.000002398987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302171,"about_ca_system_score_gemma":0.0004463073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332931,"about_ca_topic_score_gemma":0.0005580035,"domain_scores_codex":[0.9989394,0.0000285501,0.0002197919,0.0001717863,0.0004274449,0.0002130063],"domain_scores_gemma":[0.9989254,0.0001257303,0.0001431883,0.0004331662,0.0002841091,0.00008837154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008666835,0.0002674995,0.009649577,0.0002665623,0.00004350784,0.000006070326,0.001760204,0.0000210196,0.9842529,0.00005896824,0.0002764914,0.002530458],"study_design_scores_gemma":[0.0009079718,0.0004947076,0.2275023,0.001591271,0.00002156158,0.000004051236,0.001865743,0.0000233076,0.7666168,0.000009409579,0.0008877621,0.00007517428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968273,0.00005768971,0.00006033569,0.001940277,0.00007245893,0.0004639375,0.0002212397,0.000006383891,0.0003503458],"genre_scores_gemma":[0.9993823,0.0000642106,0.00001385174,0.00002645037,0.0001169477,0.00011208,0.00001551471,0.00001914629,0.0002494518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2178527,"threshold_uncertainty_score":0.2288129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09147110691658578,"score_gpt":0.4148508879130521,"score_spread":0.3233797809964663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}