{"id":"W2741423221","doi":"10.1158/1538-7445.am2017-ct131","title":"Abstract CT131: A randomized (RCT) phase II study of oncolytic reovirus (pelareorep ) plus standard weekly paclitaxel (P) as therapy for metastatic breast cancer (mBC)","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care South East; Queen's University; Juravinski Hospital; McGill University; Ottawa Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Metastatic breast cancer; Internal medicine; Clinical endpoint; Randomized controlled trial; Gastroenterology; Chemotherapy; Toxicity; Breast cancer; Paclitaxel; Surgery; Cancer; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003412568,0.001940987,0.002306679,0.0005114726,0.0005021624,0.0009585182,0.0008525683,0.002033091,0.01054583],"category_scores_gemma":[0.00316465,0.0008059961,0.002000703,0.0006264317,0.001296612,0.0009862544,0.0005714935,0.003189727,0.001223723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098961,"about_ca_system_score_gemma":0.002632769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00192189,"about_ca_topic_score_gemma":0.004676053,"domain_scores_codex":[0.9982427,0.001278884,0.00009118812,0.0001574802,0.0001107625,0.0001190082],"domain_scores_gemma":[0.9983499,0.0004799271,0.0003995345,0.0001092603,0.000136609,0.0005247982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9758977,0.00837873,0.0005781238,0.00075799,0.001261437,0.00003272609,0.00003622611,0.0002709697,0.004401627,0.0001035299,0.0008565446,0.007424496],"study_design_scores_gemma":[0.9280416,0.06928182,0.001029392,0.00002994625,0.0005420492,0.00001614279,0.00000963851,0.0001395528,0.0002804458,0.00005273619,0.0005694821,0.000007147692],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561997,0.0045715,0.00131392,0.001687966,0.0007255907,0.02758187,0.003175831,0.0001883414,0.004555189],"genre_scores_gemma":[0.9643697,0.003074938,0.003003997,0.001681003,0.0006179161,0.0176582,0.002344979,0.00003922952,0.007210006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01054583,"threshold_uncertainty_score":0.03527927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09781890425160464,"score_gpt":0.4989751244770473,"score_spread":0.4011562202254427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}