{"id":"W2741423221","doi":"10.1158/1538-7445.am2017-ct131","title":"Abstract CT131: A randomized (RCT) phase II study of oncolytic reovirus (pelareorep ) plus standard weekly paclitaxel (P) as therapy for metastatic breast cancer (mBC)","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care South East; Queen's University; Juravinski Hospital; McGill University; Ottawa Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Metastatic breast cancer; Internal medicine; Clinical endpoint; Randomized controlled trial; Gastroenterology; Chemotherapy; Toxicity; Breast cancer; Paclitaxel; Surgery; Cancer; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002425306,0.0003326216,0.0009166318,0.0001893612,0.001061678,0.000200231,0.0009012114,0.0001208883,0.0004945712],"category_scores_gemma":[0.0006206937,0.0002594323,0.0003404054,0.0001575366,0.0007496775,0.00003162795,0.0003712001,0.0003434947,0.000008079933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004883554,"about_ca_system_score_gemma":0.002652239,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02693485,"about_ca_topic_score_gemma":0.007060735,"domain_scores_codex":[0.9961804,0.000382717,0.0005398964,0.0008371127,0.001129099,0.0009308069],"domain_scores_gemma":[0.9966071,0.0002095568,0.0003346115,0.001372159,0.001110438,0.0003661396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6272456,0.005012301,0.0009526534,0.0003294645,0.004644087,0.0001223584,0.001471429,0.00006842335,0.212453,0.00008339592,0.01004988,0.1375674],"study_design_scores_gemma":[0.7559808,0.0235292,0.001678523,0.0003222155,0.0002904841,0.00001947887,0.001797894,0.00008486641,0.1940019,0.001123475,0.02042916,0.0007419596],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841132,0.006317575,0.00004924329,0.0009837812,0.0001682388,0.005614267,0.002144423,0.00001225129,0.0005969893],"genre_scores_gemma":[0.9849007,0.006555185,0.00005737726,0.0000476959,0.0003342667,0.005992019,0.00007611523,0.0000743519,0.001962313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1368254,"threshold_uncertainty_score":0.9999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09781890425160464,"score_gpt":0.4989751244770473,"score_spread":0.4011562202254427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}