{"id":"W2741428492","doi":"10.1158/1538-7445.am2017-ct055","title":"Abstract CT055: A randomized, double-blinded, controlled study of tucatinib (ONT-380) vs. placebo in combination with capecitabine (C) and trastuzumab (Tz) in patients with pretreated HER2+ unresectable locally advanced or metastatic breast carcinoma (MBC) (HER2CLIMB)","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Capecitabine; Internal medicine; Rash; Trastuzumab; Placebo; Taxane; Gastroenterology; Adverse effect; Population; Diarrhea; Oncology; Pertuzumab; Progression-free survival; Cancer; Chemotherapy; Breast cancer; Colorectal cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002555144,0.002183817,0.004145694,0.0007029916,0.0007144123,0.001361445,0.001241088,0.002476939,0.009688573],"category_scores_gemma":[0.002355823,0.0009057865,0.002094552,0.000681869,0.001713059,0.001399788,0.0004220904,0.003350618,0.00161836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001009833,"about_ca_system_score_gemma":0.001794388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001427626,"about_ca_topic_score_gemma":0.003005574,"domain_scores_codex":[0.9987988,0.0006709667,0.000101552,0.0002048749,0.0000801764,0.0001436074],"domain_scores_gemma":[0.9987078,0.0003569486,0.0002822724,0.00008525746,0.0001110829,0.0004567119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9897869,0.004096432,0.0001385478,0.000372221,0.0004149477,0.00001535018,0.00001715143,0.00007886369,0.001183069,0.00004142691,0.0002591915,0.003595898],"study_design_scores_gemma":[0.9457527,0.05278781,0.0005258546,0.00002026395,0.0002848782,0.00001060393,0.000008695809,0.0001829013,0.0001736528,0.00004009781,0.000204947,0.000007601338],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969764,0.006526088,0.001287668,0.0008014875,0.001249707,0.0143641,0.002434542,0.0002895915,0.003282875],"genre_scores_gemma":[0.9790884,0.002316655,0.001803955,0.001186582,0.0006562987,0.009764121,0.001389562,0.00002437522,0.003770075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009688573,"threshold_uncertainty_score":0.03241158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05602476690837405,"score_gpt":0.3982407936252281,"score_spread":0.3422160267168541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}