{"id":"W2741457765","doi":"10.1001/jama.2017.9362","title":"Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy","year":2017,"lang":"en","type":"article","venue":"JAMA","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":530,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of British Columbia; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Renmin Hospital of Wuhan University; Shengjing Hospital; West China Hospital, Sichuan University; Canadian Institutes of Health Research; Pfizer Pharmaceuticals; Tongji University; Genentech; First Affiliated Hospital of Zhengzhou University; George Institute for Global Health; Renji Hospital; Hebei Medical University; Baotou Medical College; Tongji Medical College, Huazhong University of Science and Technology; National Health and Medical Research Council; Nanjing University; Peking University; Medical Research Council; Zhejiang University; School of Medicine, Indiana University; Relypsa; Wuhan University; Henan University; Ruijin Hospital; University of Leicester; Nanjing General Hospital of Nanjing Military Command; Zhengzhou University; Fresenius Medical Care North America; University of British Columbia; Eli Lilly and Company; Pfizer; Charles Darwin University; Diabetes Australia; Huazhong University of Science and Technology; Janssen Research and Development; Akebia Therapeutics; Diabetes Australia Research Trust; China Medical University; Sanofi; Henan University of Science and Technology; Huashan Hospital; Rebecca L. Cooper Medical Research Foundation; Omeros Corporation; David Geffen School of Medicine, University of California, Los Angeles; Peking University People's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; Postgraduate Institute of Medical Education and Research, Chandigarh; Qilu Hospital of Shandong University; Sichuan University; Shandong University; Johns Hopkins University; Chugai Pharmaceutical; General Hospital of People’s Liberation Army; Menzies School of Health Research; Shanxi Medical University; Amgen; Fudan University; Peking University First Hospital","keywords":"Medicine; Nephropathy; Renal function; Proteinuria; Internal medicine; Kidney disease; Gastroenterology; Randomized controlled trial; Methylprednisolone; Urology; Diabetes mellitus; Kidney; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004154433,0.000124315,0.0005522364,0.00006289084,0.00004570369,0.00002089584,0.000109594,0.00008243285,0.0000185067],"category_scores_gemma":[0.001203852,0.00006968674,0.000147958,0.00003875975,0.0001474967,0.00008378602,0.00004903349,0.0001721254,0.00002722137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001448541,"about_ca_system_score_gemma":0.00002560225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288792,"about_ca_topic_score_gemma":0.00001326577,"domain_scores_codex":[0.9989935,0.0001203727,0.0002767809,0.0001862372,0.000272224,0.0001508787],"domain_scores_gemma":[0.9989149,0.0001980203,0.0001820723,0.0005353567,0.00006367407,0.0001059908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005488862,0.0004452867,0.9288359,0.00008935931,0.0000682153,0.00004111341,0.00002045817,9.223738e-7,0.000008321977,0.00001796654,0.0002413034,0.06474235],"study_design_scores_gemma":[0.01112048,0.009090408,0.9789095,0.0002133226,0.0001156758,4.336086e-7,0.000004212291,0.00001267811,0.0002673986,0.00001341157,0.0001804738,0.00007202715],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980763,0.0000440461,0.000002025868,0.0004462441,0.0001242528,0.0003284949,0.00001918149,0.00001523882,0.000944167],"genre_scores_gemma":[0.9994344,0.00002084898,0.00009395089,0.0002529664,0.00004504324,0.00001032547,0.00001273163,0.00001279898,0.0001169254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06467032,"threshold_uncertainty_score":0.2841743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802635962345144,"score_gpt":0.3494603316194959,"score_spread":0.3314339719960445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}