{"id":"W2741457765","doi":"10.1001/jama.2017.9362","title":"Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy","year":2017,"lang":"en","type":"article","venue":"JAMA","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":530,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of British Columbia; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Renmin Hospital of Wuhan University; Shengjing Hospital; West China Hospital, Sichuan University; Canadian Institutes of Health Research; Pfizer Pharmaceuticals; Tongji University; Genentech; First Affiliated Hospital of Zhengzhou University; George Institute for Global Health; Renji Hospital; Hebei Medical University; Baotou Medical College; Tongji Medical College, Huazhong University of Science and Technology; National Health and Medical Research Council; Nanjing University; Peking University; Medical Research Council; Zhejiang University; School of Medicine, Indiana University; Relypsa; Wuhan University; Henan University; Ruijin Hospital; University of Leicester; Nanjing General Hospital of Nanjing Military Command; Zhengzhou University; Fresenius Medical Care North America; University of British Columbia; Eli Lilly and Company; Pfizer; Charles Darwin University; Diabetes Australia; Huazhong University of Science and Technology; Janssen Research and Development; Akebia Therapeutics; Diabetes Australia Research Trust; China Medical University; Sanofi; Henan University of Science and Technology; Huashan Hospital; Rebecca L. Cooper Medical Research Foundation; Omeros Corporation; David Geffen School of Medicine, University of California, Los Angeles; Peking University People's Hospital; National Institute of Diabetes and Digestive and Kidney Diseases; Postgraduate Institute of Medical Education and Research, Chandigarh; Qilu Hospital of Shandong University; Sichuan University; Shandong University; Johns Hopkins University; Chugai Pharmaceutical; General Hospital of People’s Liberation Army; Menzies School of Health Research; Shanxi Medical University; Amgen; Fudan University; Peking University First Hospital","keywords":"Medicine; Nephropathy; Renal function; Proteinuria; Internal medicine; Kidney disease; Gastroenterology; Randomized controlled trial; Methylprednisolone; Urology; Diabetes mellitus; Kidney; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002779956,0.0005823453,0.001237282,0.0002206011,0.0002352962,0.0004759078,0.0003285564,0.0009740448,0.001947397],"category_scores_gemma":[0.005463365,0.0001663684,0.001400904,0.0002619103,0.0003959294,0.0003449413,0.0002975386,0.001127498,0.0002490458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003468663,"about_ca_system_score_gemma":0.0005490124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004871322,"about_ca_topic_score_gemma":0.001151435,"domain_scores_codex":[0.9987805,0.0008076935,0.0001115222,0.0000843418,0.0001295677,0.00008630956],"domain_scores_gemma":[0.9969687,0.001353927,0.0008506499,0.0001494922,0.0001880452,0.0004893548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7527041,0.006383421,0.07040055,0.001597317,0.004136607,0.00009453095,0.00007727586,0.0004930192,0.002490385,0.00008287652,0.001618184,0.1599217],"study_design_scores_gemma":[0.3935947,0.2487785,0.3430668,0.000729485,0.006528344,0.0002570598,0.00009232981,0.001788867,0.001927581,0.0004599773,0.002725688,0.00005057447],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759956,0.02043905,0.0002260363,0.0009665074,0.0002803356,0.000301281,0.0003164657,0.00002703659,0.001447702],"genre_scores_gemma":[0.9960373,0.002255688,0.0003515875,0.0004700741,0.0002385594,0.0001752488,0.0001970937,0.000002393188,0.0002720972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779956,"threshold_uncertainty_score":0.01470202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802635962345144,"score_gpt":0.3494603316194959,"score_spread":0.3314339719960445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}