{"id":"W2741466867","doi":"10.1158/1538-7445.am2017-3298","title":"Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1)","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Autophagy; LNCaP; AMPK; Chemistry; Downregulation and upregulation; Vacuole; Cancer research; Cell biology; Small interfering RNA; Cancer cell; Transfection; Apoptosis; Biology; Protein kinase A; Kinase; Cancer; Biochemistry; Cytoplasm; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005241582,0.0002066527,0.0001280103,0.0001221772,0.00007727311,0.00009089604,0.0001317482,0.000149408,0.002008527],"category_scores_gemma":[0.00003946686,0.00009456211,0.0001529895,0.0001393396,0.00007740565,0.00009590897,0.00009571491,0.0003012501,0.0005003671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001448841,"about_ca_system_score_gemma":0.0001411867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232904,"about_ca_topic_score_gemma":0.0006321396,"domain_scores_codex":[0.9999499,0.000007442183,0.000004220981,0.00001005635,0.00001492618,0.00001347479],"domain_scores_gemma":[0.9999789,0.000002924782,0.000005135228,0.000003009732,0.00000301138,0.000007040692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295507,0.00002369567,0.00006703642,0.0000369085,0.000003476614,0.00002573544,0.000005362072,0.00003667111,0.9986285,0.00004115372,0.00009411794,0.0009078651],"study_design_scores_gemma":[0.00001800101,0.0002783159,0.001767364,0.000002222956,0.00000554538,0.0001259169,0.000005519664,0.0002745718,0.9954665,0.00001410068,0.002039993,0.000001977485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915175,0.002255001,0.001342402,0.0001187097,0.00004235224,0.00003636501,0.0008132154,0.0001124289,0.003762159],"genre_scores_gemma":[0.9925941,0.0009283745,0.001345474,0.00007719978,0.00001110111,0.00004591347,0.001093917,0.00001833475,0.00388559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008527,"threshold_uncertainty_score":0.006719172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011408300960917,"score_gpt":0.4172872777588086,"score_spread":0.3161464476627168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}