{"id":"W2741548122","doi":"10.1158/1538-7445.am2017-ct046","title":"Abstract CT046: Phase I dose escalation study of the CDK4/6 inhibitor palbociclib in combination with the MEK inhibitor PD-0325901 in patients with <i>RAS</i> mutant solid tumors","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Palbociclib; Medicine; Tolerability; Pharmacokinetics; Pharmacology; Neutropenia; Leukopenia; Internal medicine; Oncology; Cancer; Adverse effect; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009711764,0.0002182283,0.0003967361,0.0002208035,0.0003884332,0.00007080589,0.0004507485,0.00006876481,0.00004471107],"category_scores_gemma":[0.0001655515,0.000115572,0.00003707911,0.00059812,0.0006314482,0.0003862927,0.0001521615,0.0008645725,0.000002979601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005878658,"about_ca_system_score_gemma":0.0004628369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179266,"about_ca_topic_score_gemma":0.004133215,"domain_scores_codex":[0.996895,0.0002169328,0.0004237423,0.0004339492,0.001527505,0.0005029211],"domain_scores_gemma":[0.9978116,0.0001545821,0.0003574288,0.0009637959,0.0006121269,0.0001004827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01643385,0.005776777,0.9221536,0.0001886433,0.0001097254,0.00005579659,0.0093281,0.0003983154,0.01872931,0.00002923827,0.00008696723,0.02670971],"study_design_scores_gemma":[0.03094416,0.002218239,0.9452803,0.0009467469,0.00001993042,0.000001863327,0.002828209,0.0000477101,0.01738137,0.00007578694,0.0001093663,0.0001463403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945274,0.00009063914,0.000003993478,0.001795295,0.000108196,0.003270155,0.00002585345,0.00001475211,0.0001636874],"genre_scores_gemma":[0.9991488,0.00001310061,0.00001166496,0.00005532538,0.000132794,0.0005014245,0.000008985514,0.00005102822,0.00007685698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02656337,"threshold_uncertainty_score":0.4712888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03961281957013143,"score_gpt":0.3934869420847642,"score_spread":0.3538741225146328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}