{"id":"W2741588972","doi":"10.1002/pros.23393","title":"Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples","year":2017,"lang":"en","type":"article","venue":"The Prostate","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Prostate Cancer Canada; Lawson Health Research Institute","keywords":"Extracellular vesicles; Microvesicles; Chemistry; Flow cytometry; Chromatography; Exosome; Antibody; Analyte; Extracellular vesicle; Molecular biology; Biology; Biochemistry; Cell biology; microRNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007749817,0.0002270628,0.0002440117,0.00003152264,0.0004497796,0.0001154982,0.0008049805,0.0001048651,0.00001289325],"category_scores_gemma":[0.001057533,0.0001864519,0.0001548242,0.00004250655,0.000271685,0.00001476276,0.000216077,0.00008711617,0.00000828569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001529697,"about_ca_system_score_gemma":0.0001151047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001033137,"about_ca_topic_score_gemma":0.00005958231,"domain_scores_codex":[0.9984735,0.0002294848,0.000373561,0.0004645396,0.0001430312,0.0003159473],"domain_scores_gemma":[0.9975694,0.0001196382,0.000439192,0.001535875,0.0002178607,0.0001180708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009719694,0.0001013134,0.003129074,0.00005739289,0.00006739148,0.000001606625,0.0003643826,0.000134074,0.9801218,0.00006436195,0.000106831,0.01487982],"study_design_scores_gemma":[0.0009623065,0.0001613652,0.03352422,0.00004482746,0.00007155945,8.071452e-7,0.0001930267,0.0007706098,0.9582772,0.0009748421,0.004786857,0.0002323986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714931,0.001141456,0.02396746,0.0009294775,0.0001406779,0.001375547,0.0009065015,0.00002111775,0.00002463528],"genre_scores_gemma":[0.9360722,0.00006235095,0.06281342,0.00008737017,0.00008904158,0.000302402,0.0003217715,0.00005181528,0.0001996648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03884596,"threshold_uncertainty_score":0.7603289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352780073105599,"score_gpt":0.3185548756945139,"score_spread":0.283276868383954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}