{"id":"W2741588972","doi":"10.1002/pros.23393","title":"Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples","year":2017,"lang":"en","type":"article","venue":"The Prostate","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Prostate Cancer Canada; Lawson Health Research Institute","keywords":"Extracellular vesicles; Microvesicles; Chemistry; Flow cytometry; Chromatography; Exosome; Antibody; Analyte; Extracellular vesicle; Molecular biology; Biology; Biochemistry; Cell biology; microRNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00329752,0.001210816,0.0008514415,0.001336594,0.0005945791,0.002260575,0.001312273,0.002290965,0.008524895],"category_scores_gemma":[0.006607998,0.0005477909,0.0007867898,0.0008659757,0.0006668589,0.001363816,0.0008370712,0.001383635,0.006739085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007603217,"about_ca_system_score_gemma":0.0006818381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007474551,"about_ca_topic_score_gemma":0.001357935,"domain_scores_codex":[0.9930096,0.001765971,0.0006246158,0.001377382,0.002848593,0.0003738854],"domain_scores_gemma":[0.9945152,0.002717414,0.0007747581,0.0005105709,0.001327438,0.0001544663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004381891,0.0001889817,0.002226974,0.001751625,0.0001473836,0.0001808466,0.0001567519,0.0005063635,0.9533314,0.0009631407,0.001594772,0.03851346],"study_design_scores_gemma":[0.00004158946,0.0006962405,0.01033168,0.0002725121,0.0002140921,0.0008830478,0.0001413595,0.002883289,0.9466709,0.0007915793,0.03701482,0.0000587809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4342078,0.04928888,0.4726266,0.004298302,0.002004424,0.002218537,0.005115724,0.004516303,0.02572344],"genre_scores_gemma":[0.676043,0.01588088,0.2753116,0.00251638,0.0006709952,0.00167092,0.007172821,0.000884937,0.01984849],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008524895,"threshold_uncertainty_score":0.02851862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352780073105599,"score_gpt":0.3185548756945139,"score_spread":0.283276868383954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}