{"id":"W2741620700","doi":"10.1371/journal.pone.0181551","title":"Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Supercomputer Centre, Linköpings Universitet; Göteborgs Universitet; Vetenskapsrådet; University of Toronto; Cancerfonden; National Science Council; Swedish Foundation for International Cooperation in Research and Higher Education; Swedish Cancer Foundation","keywords":"Ubiquitin ligase; Chemistry; Nuclear magnetic resonance spectroscopy; Protein Data Bank (RCSB PDB); Trim; Ring (chemistry); Protein structure; Docking (animal); Coiled coil; Crystallography; Stereochemistry; Ubiquitin; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001647133,0.00005595536,0.0001249966,0.000043655,0.0001629879,0.0000134264,0.0001781801,0.0000680673,0.00001960465],"category_scores_gemma":[0.0001447857,0.00003097635,0.00001742698,0.00003099466,0.0002051438,0.0001142101,0.00006539337,0.0001537208,0.000002251538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001528865,"about_ca_system_score_gemma":0.00001787715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001220316,"about_ca_topic_score_gemma":0.0007062125,"domain_scores_codex":[0.9994785,0.0001604663,0.0001680417,0.00008706844,0.00003062605,0.00007526514],"domain_scores_gemma":[0.9992996,0.00006419394,0.0002934436,0.0002783811,0.00006174558,0.00000261605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006621029,0.00008131129,0.005234588,0.0000377198,0.00009281228,7.706556e-8,0.001222048,6.88529e-7,0.9922696,0.0001731807,0.00001764711,0.0002082062],"study_design_scores_gemma":[0.0004240644,0.0000645946,0.214446,0.0001769191,0.00002837924,0.000001814114,0.0005231522,0.000006198151,0.7842153,0.00006455766,0.00002121806,0.00002782211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983019,0.0007336249,0.00001081377,0.0006186722,0.0000515508,0.000186516,0.00000900943,0.00000402222,0.00008392709],"genre_scores_gemma":[0.9994396,0.00006220739,0.00001147788,0.00001033787,0.000006324019,0.000004320881,0.000004448351,0.00000407934,0.0004572064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2092114,"threshold_uncertainty_score":0.1263179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02991103363515368,"score_gpt":0.2454807971961391,"score_spread":0.2155697635609854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}