{"id":"W2741620700","doi":"10.1371/journal.pone.0181551","title":"Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Supercomputer Centre, Linköpings Universitet; Göteborgs Universitet; Vetenskapsrådet; University of Toronto; Cancerfonden; National Science Council; Swedish Foundation for International Cooperation in Research and Higher Education; Swedish Cancer Foundation","keywords":"Ubiquitin ligase; Chemistry; Nuclear magnetic resonance spectroscopy; Protein Data Bank (RCSB PDB); Trim; Ring (chemistry); Protein structure; Docking (animal); Coiled coil; Crystallography; Stereochemistry; Ubiquitin; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479361,0.0002597856,0.0002102609,0.0001759129,0.000429508,0.0002131044,0.000474382,0.0006372993,0.001795823],"category_scores_gemma":[0.0002438775,0.0001633482,0.0001929919,0.0002522442,0.0002019859,0.0002852154,0.0002158708,0.0008241856,0.000393183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003548334,"about_ca_system_score_gemma":0.0003345014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274206,"about_ca_topic_score_gemma":0.001570185,"domain_scores_codex":[0.9999468,0.00000906023,0.000002548232,0.0000126992,0.00002051506,0.000008436426],"domain_scores_gemma":[0.9999031,0.00001435494,0.00002066159,0.000007705057,0.00002372306,0.00003055138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003669353,0.00007102275,0.0008294577,0.0001811127,0.00003122137,0.0002683046,0.000137204,0.002130128,0.9903982,0.0006085336,0.0008949228,0.004083152],"study_design_scores_gemma":[0.0002653516,0.0009478714,0.04095185,0.0001029582,0.0002297197,0.002335411,0.0006746746,0.07040565,0.8462225,0.002316615,0.03540122,0.0001462405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834917,0.002985354,0.007827921,0.0008090317,0.00006726359,0.00003230308,0.00126841,0.0001266838,0.003391359],"genre_scores_gemma":[0.9708714,0.001974225,0.01709336,0.0002815129,0.00006740316,0.00003539899,0.007007825,0.00004019242,0.00262868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795823,"threshold_uncertainty_score":0.006007671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02991103363515368,"score_gpt":0.2454807971961391,"score_spread":0.2155697635609854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}