{"id":"W2741630207","doi":"10.1016/j.dld.2017.07.010","title":"Indicators of suboptimal tumor necrosis factor antagonist therapy in inflammatory bowel disease","year":2017,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"Takeda Pharmaceuticals International","keywords":"Medicine; Inflammatory bowel disease; Tumor necrosis factor alpha; Internal medicine; Disease; Tumor necrosis factor α; Gastroenterology; Antagonist; Oncology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009691327,0.0002709932,0.0001757164,0.0001111542,0.0002509583,0.00009941239,0.0003522662,0.00006891964,0.00004326166],"category_scores_gemma":[0.0002019443,0.0002608842,0.0001406994,0.00003214532,0.0006097918,0.00003663496,0.0002181936,0.00009803846,0.000007710015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001888172,"about_ca_system_score_gemma":0.0003243329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004933325,"about_ca_topic_score_gemma":0.00002037784,"domain_scores_codex":[0.9986824,0.0000803562,0.0002547583,0.0004838515,0.0001885809,0.0003100176],"domain_scores_gemma":[0.9983426,0.00001449062,0.0002456278,0.0006975718,0.00007261791,0.0006271179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002657442,0.0002235427,0.9912741,0.00009837766,0.0000482002,0.0005871533,0.0001086433,0.000009774806,0.00376652,0.0001799647,0.00009154993,0.0009547577],"study_design_scores_gemma":[0.001340457,0.00007406074,0.9953603,0.00005379391,0.00003442931,6.086615e-7,0.00002758414,0.00005891341,0.002081281,0.00004392222,0.0006116935,0.0003130079],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975576,0.001111605,0.000005162883,0.00005787712,0.00007262093,0.0004119763,0.0005744312,0.00001231162,0.000196462],"genre_scores_gemma":[0.9988373,0.0005672037,0.00001936859,0.0001652554,0.00009892439,0.0000644853,0.0001015442,0.00003285636,0.000113045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004086175,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008888597898468388,"score_gpt":0.2418755903712055,"score_spread":0.2329869924727371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}