{"id":"W2741638387","doi":"10.1021/acsinfecdis.7b00068","title":"Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Division of Graduate Education; National Human Genome Research Institute","keywords":"Acetyltransferases; Enzyme; Sisomicin; Tobramycin; Acetyltransferase; Aminoglycoside; Biochemistry; Biology; Microbiology; Antibiotic resistance; Gentamicin; Chemistry; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220522,0.0002881424,0.0001457873,0.0003005619,0.0001055028,0.0002777361,0.0001158931,0.0002587082,0.0004868651],"category_scores_gemma":[0.0002569028,0.00008229208,0.0002230239,0.0004139689,0.0001398909,0.0001671648,0.0001674625,0.000202791,0.0002044412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533526,"about_ca_system_score_gemma":0.0001898131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067827,"about_ca_topic_score_gemma":0.001244171,"domain_scores_codex":[0.99989,0.00001671136,0.00001028499,0.00002452486,0.00003552808,0.00002306745],"domain_scores_gemma":[0.9998846,0.00001612862,0.00003911565,0.00001174371,0.0000215322,0.00002688705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001441069,0.00003052678,0.01493525,0.00006474283,0.0000237682,0.0001198236,0.00004842244,0.0002815019,0.9787651,0.0001184929,0.00006129401,0.005407042],"study_design_scores_gemma":[0.00001453335,0.0006086302,0.4470942,0.00002936739,0.0001101098,0.002005148,0.000444759,0.004050205,0.534543,0.0003295754,0.01074005,0.0000304234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967225,0.001014086,0.0007743653,0.00005265598,0.000003036515,0.000004106642,0.0005985675,0.00001818673,0.0008124044],"genre_scores_gemma":[0.9954638,0.0008424381,0.001474606,0.00002745727,0.000004749585,0.000004256729,0.001691835,0.000008143552,0.00048275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067827,"threshold_uncertainty_score":0.002123177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418661847953355,"score_gpt":0.2467458565749299,"score_spread":0.2325592380953963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}