{"id":"W2741638387","doi":"10.1021/acsinfecdis.7b00068","title":"Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Division of Graduate Education; National Human Genome Research Institute","keywords":"Acetyltransferases; Enzyme; Sisomicin; Tobramycin; Acetyltransferase; Aminoglycoside; Biochemistry; Biology; Microbiology; Antibiotic resistance; Gentamicin; Chemistry; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174423,0.0001436046,0.0002120623,0.00002319625,0.0002058375,0.00002579182,0.000124727,0.00007988243,0.00006070552],"category_scores_gemma":[0.0004067816,0.0001378567,0.00006797611,0.00002080152,0.000617162,0.00001730733,0.00008564172,0.0000417357,7.748191e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001374734,"about_ca_system_score_gemma":0.00004853495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001196044,"about_ca_topic_score_gemma":0.000395938,"domain_scores_codex":[0.9990801,0.00009001344,0.0002550814,0.0002852446,0.0001582289,0.0001313566],"domain_scores_gemma":[0.9990806,0.00006794478,0.0002435369,0.0004776321,0.00006756072,0.00006275278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002923475,0.00005481638,0.8078099,0.00005692449,0.00008352016,6.722037e-7,0.000004709874,0.000003599266,0.1911065,0.0001120851,0.0003212411,0.0001536822],"study_design_scores_gemma":[0.0004469887,0.00008908531,0.9331714,0.00002243728,0.00004153906,0.000004798794,0.00001332649,5.52241e-7,0.06576788,0.0002455215,0.00007249108,0.0001239932],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964542,0.001592994,0.00008970048,0.00001412671,0.0001606731,0.0001179674,0.001399011,0.00000655742,0.000164755],"genre_scores_gemma":[0.9990045,0.0003565497,0.00002510338,0.00002330448,0.00007677385,0.000004275048,0.0002718256,0.00001307602,0.0002245353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1253615,"threshold_uncertainty_score":0.5621635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418661847953355,"score_gpt":0.2467458565749299,"score_spread":0.2325592380953963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}