{"id":"W2741655923","doi":"10.1158/1538-7445.am2017-319","title":"Abstract 319: Cholesterol inhibition reduces Hh mediated chondrosarcoma","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children","funders":"","keywords":"Lovastatin; In vivo; Cholesterol; Simvastatin; HMG-CoA reductase; Pharmacology; High cholesterol; Endocrinology; Internal medicine; Biology; Chemistry; Medicine; Reductase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008680704,0.0003500324,0.0004878364,0.0003396811,0.0001788178,0.0002412687,0.0002694386,0.000312454,0.003500733],"category_scores_gemma":[0.00007316171,0.0001098087,0.0002197917,0.0002518283,0.0002191391,0.0001193261,0.0001658794,0.0006018772,0.001050283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573161,"about_ca_system_score_gemma":0.0004130243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319118,"about_ca_topic_score_gemma":0.0023055,"domain_scores_codex":[0.9998519,0.00001718065,0.00002261132,0.00001568122,0.00004735147,0.00004526179],"domain_scores_gemma":[0.9999053,0.00001094757,0.00002296348,0.000009338001,0.00001298856,0.00003840406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008055119,0.0003009342,0.0001833897,0.0001032247,0.00001362234,0.00007390088,0.0000189419,0.00006678132,0.9943959,0.00008544639,0.0003450602,0.003607275],"study_design_scores_gemma":[0.0001404261,0.002891065,0.00343667,0.00001083108,0.00003064151,0.0002279579,0.00003707634,0.0003871969,0.9890373,0.00003236799,0.00376232,0.000006193166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917859,0.001823798,0.0005475106,0.0001825301,0.00007570017,0.00008486689,0.001151293,0.000195017,0.004153298],"genre_scores_gemma":[0.9882709,0.001394481,0.0007299749,0.0000981847,0.00002785313,0.00006679822,0.00173133,0.0000253837,0.007655071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003500733,"threshold_uncertainty_score":0.01171112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05995871721572353,"score_gpt":0.3962895581012677,"score_spread":0.3363308408855442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}