{"id":"W2741722655","doi":"10.1158/1538-7445.am2017-3960","title":"Abstract 3960: Tumor cell drug resistance induced by the programmed death ligand 1 (PD-L1) immune checkpoint is associated with autophagy","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Autophagy; Protein kinase B; PI3K/AKT/mTOR pathway; Cell biology; Cancer research; Programmed cell death; Signal transduction; MAPK/ERK pathway; Immune checkpoint; Cancer cell; Biology; Kinase; Cytotoxic T cell; Immune system; Chemistry; Cancer; Apoptosis; Immunology; Immunotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544374,0.0003396217,0.0004693198,0.0003784809,0.0002470938,0.0002589533,0.0002291704,0.0002785879,0.007698954],"category_scores_gemma":[0.0001079496,0.0001136384,0.0003522247,0.0002603286,0.0001630736,0.0002021516,0.0002203028,0.0006061777,0.002064764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003977007,"about_ca_system_score_gemma":0.0002247273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003184,"about_ca_topic_score_gemma":0.0002593295,"domain_scores_codex":[0.9998795,0.00001718384,0.00001272652,0.00002470154,0.00003506768,0.00003081539],"domain_scores_gemma":[0.9999311,0.00001487825,0.00001186747,0.00000791924,0.0000124608,0.00002164921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007389029,0.0001898879,0.0002614128,0.0001561341,0.00001127803,0.0001871894,0.000009906447,0.00008250852,0.9917401,0.0002782982,0.0008495839,0.005494821],"study_design_scores_gemma":[0.0001370515,0.001004169,0.006253314,0.00001991234,0.00002263349,0.0006676367,0.00001472718,0.0005981941,0.9787312,0.0002517676,0.01229091,0.000008495365],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95396,0.009641068,0.005316117,0.00114048,0.0005439606,0.0002781629,0.005085545,0.0006654812,0.02336923],"genre_scores_gemma":[0.9556953,0.003803182,0.005341067,0.0006311565,0.0001375246,0.0002544101,0.007648559,0.000103567,0.02638523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007698954,"threshold_uncertainty_score":0.02575558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06270573317777184,"score_gpt":0.3857097267998381,"score_spread":0.3230039936220663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}