{"id":"W2741774018","doi":"10.1080/15384101.2017.1356512","title":"Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells","year":2017,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Australian Research Council; Griffith University; Prostate Cancer Foundation of Australia; Medical Research Council; Department of Health and Aged Care, Australian Government; Movember Foundation; Australian Government; Prostate Cancer Foundation","keywords":"Biology; LNCaP; Mitosis; Microtubule; Microtubule polymerization; Cell biology; Vinblastine; Paclitaxel; Cancer research; Cancer cell; Tubulin; Apoptosis; Programmed cell death; Mitotic catastrophe; Cancer; Biochemistry; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006827225,0.0001997623,0.000149598,0.0002314791,0.0001037648,0.0002116937,0.0001623858,0.0001865353,0.0004113388],"category_scores_gemma":[0.0000453293,0.00007128877,0.0001252448,0.0001134577,0.0001237396,0.0001600775,0.0001213545,0.0002776977,0.000163338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582939,"about_ca_system_score_gemma":0.000185852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003513301,"about_ca_topic_score_gemma":0.0009007865,"domain_scores_codex":[0.9999748,0.000004676635,0.000001573639,0.000004739987,0.00000721401,0.000006910137],"domain_scores_gemma":[0.9999769,0.000002489142,0.000005478409,0.000001934525,0.000005273295,0.000007956311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171123,0.00004707024,0.0003204655,0.0001167876,0.00001207012,0.0002382215,0.00002159522,0.0002955064,0.9795716,0.0005379115,0.0002097241,0.01851192],"study_design_scores_gemma":[0.00006134797,0.001112707,0.002431989,0.00001071316,0.00003596349,0.0007816336,0.00001212896,0.0009445298,0.9776695,0.0001274988,0.01680449,0.000007456348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639323,0.02111503,0.006830389,0.000599029,0.00007471698,0.0001561816,0.0004365262,0.0001672931,0.006688616],"genre_scores_gemma":[0.9833018,0.008489672,0.004455226,0.0001182648,0.0000336784,0.00003127948,0.0003879134,0.00001084699,0.003171312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004113388,"threshold_uncertainty_score":0.001874089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945611120048925,"score_gpt":0.2473835749214179,"score_spread":0.2404379638013689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}