{"id":"W2741843640","doi":"10.1158/1538-7445.am2017-151","title":"Abstract 151: Inhibition of AKT-1 for the treatment of human non-small cell lung cancer (NSCLC) in-vitro","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Protein kinase B; Cancer research; PI3K/AKT/mTOR pathway; Carcinogenesis; Biology; Cell growth; Chemistry; Phosphorylation; Cancer; Medicine; Cell biology; Signal transduction; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574263,0.0004288604,0.0004057128,0.0002743817,0.0001935264,0.0003144892,0.0002709569,0.0002950378,0.003345811],"category_scores_gemma":[0.00009510008,0.0001534754,0.000511109,0.0002473387,0.0001088161,0.0001551363,0.0001404812,0.0007743838,0.001072685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183162,"about_ca_system_score_gemma":0.0005870328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294123,"about_ca_topic_score_gemma":0.003521859,"domain_scores_codex":[0.9998628,0.00003043673,0.00001903818,0.0000186143,0.00004242556,0.00002665058],"domain_scores_gemma":[0.9999652,0.000006538817,0.000005850334,0.000004493853,0.000007835319,0.00001005498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001067323,0.001312346,0.0004138921,0.0005072575,0.00005429935,0.0001635895,0.00003774336,0.0005997759,0.9737758,0.0003364293,0.002815612,0.01891595],"study_design_scores_gemma":[0.0004127822,0.005721054,0.005385919,0.00003854338,0.0001286866,0.0005465806,0.00002670387,0.001213268,0.9660926,0.00008378505,0.02033726,0.00001285521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397959,0.031518,0.004423669,0.0009995843,0.0009992102,0.0007544553,0.006191004,0.0004042449,0.01491397],"genre_scores_gemma":[0.9594278,0.01344526,0.004570728,0.0004281982,0.00008651602,0.0003671174,0.006871842,0.00003893176,0.0147637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003345811,"threshold_uncertainty_score":0.01119286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1134463908440666,"score_gpt":0.4491319886383134,"score_spread":0.3356855977942469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}