{"id":"W2741865238","doi":"10.1016/j.molcel.2017.06.033","title":"Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition","year":2017,"lang":"en","type":"article","venue":"Molecular Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Occupational Cancer Research Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"mTORC1; PI3K/AKT/mTOR pathway; Biology; Protein kinase B; Cancer research; Cell biology; Integrin; Insulin-like growth factor 1 receptor; Focal adhesion; Signal transduction; Cell growth; Cell; Growth factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447521,0.0004400067,0.000325415,0.0003394393,0.0003046194,0.0004555119,0.0002399601,0.0002607353,0.001819679],"category_scores_gemma":[0.0001132191,0.0001732264,0.0002735463,0.0002076786,0.0002123967,0.0002239254,0.0002253841,0.0008475545,0.0003476219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000653934,"about_ca_system_score_gemma":0.0004291764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002259755,"about_ca_topic_score_gemma":0.004222528,"domain_scores_codex":[0.9998453,0.00001850932,0.000008888258,0.00001535902,0.00003512391,0.00007679835],"domain_scores_gemma":[0.9999591,0.000005122047,0.000008971198,0.000005494034,0.00000668658,0.00001463514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000853523,0.000204104,0.0008648743,0.0001083339,0.00003479121,0.0002007365,0.00003991411,0.0005304686,0.9843892,0.001281297,0.001371419,0.01012137],"study_design_scores_gemma":[0.0001509951,0.0008878234,0.01558626,0.00001128929,0.00006167201,0.0005763871,0.0001089379,0.003687236,0.9681345,0.0002446559,0.01053497,0.00001537431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872783,0.00364151,0.001429758,0.0005631936,0.00009187606,0.00006425028,0.0005535575,0.0001919369,0.006185445],"genre_scores_gemma":[0.9952467,0.0009364727,0.0005009755,0.00007561853,0.00001312315,0.00006178754,0.0003289754,0.00001020627,0.002826145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002259755,"threshold_uncertainty_score":0.006087422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069050047234005,"score_gpt":0.2321294033922501,"score_spread":0.22143890291991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}