{"id":"W2741866963","doi":"10.1093/ijnp/pyx066","title":"A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR","year":2017,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Advancing Health Outcomes; TRIUMF; University of British Columbia","funders":"","keywords":"Norepinephrine transporter; Quetiapine; Norepinephrine; Internal medicine; Serotonin transporter; Locus coeruleus; Endocrinology; Medicine; Psychology; Psychiatry; Dopamine; Serotonin; Receptor; Schizophrenia (object-oriented programming); Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002280878,0.0001913705,0.0002650208,0.0003726642,0.0001055836,0.00004966522,0.0008749269,0.00003687183,0.00003446743],"category_scores_gemma":[0.00007984899,0.0001176703,0.00004781992,0.0001568424,0.0001558401,0.0004215422,0.00004141763,0.0003806456,0.000001013318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002550247,"about_ca_system_score_gemma":0.00003750493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002058134,"about_ca_topic_score_gemma":0.000009813385,"domain_scores_codex":[0.9979589,0.0004351196,0.0005462753,0.0002869794,0.0006075843,0.0001651566],"domain_scores_gemma":[0.9982426,0.0002207765,0.0009037443,0.0002198617,0.0003300588,0.00008295958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03138344,0.0008643067,0.4705575,0.000003437719,0.00002893239,0.000395172,0.0004018645,0.0001068785,0.4958427,0.000001494082,0.000008950589,0.0004053049],"study_design_scores_gemma":[0.01121021,0.004068373,0.9183291,0.00008535756,0.00008856077,0.0002701074,0.00001509172,0.0001122731,0.06568448,0.000004244705,0.0000280937,0.0001041271],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981885,0.00001359265,0.00001310648,0.0008322373,0.0003072392,0.0006015724,0.00001246517,0.000009569013,0.00002170296],"genre_scores_gemma":[0.9995086,0.00003880057,0.00001299852,0.000342376,0.00003498284,0.0000167475,7.078802e-7,0.00002346624,0.00002134666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4477715,"threshold_uncertainty_score":0.4798454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919599969291553,"score_gpt":0.3144167522408836,"score_spread":0.295220752547968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}