{"id":"W2741869046","doi":"10.1158/1538-7445.am2017-ct038","title":"Abstract CT038: A phase I, open-label, dose-escalation study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of GSK3326595 in subjects with solid tumors and non-Hodgkin's lymphoma","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Pharmacodynamics; Pharmacokinetics; Pharmacology; Lymphoma; Oncology; Toxicity; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001944167,0.0001751691,0.0002876878,0.000102835,0.0003246344,0.0001570634,0.0005283009,0.00009381567,0.000008807919],"category_scores_gemma":[0.0001815248,0.0001396187,0.00001997335,0.0001739996,0.0006768891,0.00003488561,0.0007355936,0.0002814273,9.981632e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009445081,"about_ca_system_score_gemma":0.0004917572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002417688,"about_ca_topic_score_gemma":0.005165511,"domain_scores_codex":[0.9981026,0.0002661037,0.0003485574,0.0005984983,0.0003359345,0.0003482968],"domain_scores_gemma":[0.9986639,0.00007844362,0.0002194017,0.0005857256,0.0002473542,0.0002051763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007887641,0.001309281,0.06323116,0.00007087074,0.0002096753,0.00001780151,0.0004534953,0.000557115,0.7937227,0.000004123033,0.0003390049,0.1321972],"study_design_scores_gemma":[0.01764303,0.002417879,0.7930932,0.0001577964,0.00004987821,0.00000616968,0.0001470178,0.003844737,0.1819816,0.0000311824,0.0003683004,0.0002592327],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965117,0.0002729417,0.00003425259,0.001050277,0.000103156,0.00184692,0.00004580949,0.000003907084,0.0001310671],"genre_scores_gemma":[0.9983444,0.001141164,0.00004986956,0.00004229406,0.0001809668,0.0001121568,0.00001290264,0.00003210494,0.00008417472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.729862,"threshold_uncertainty_score":0.5693484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0878451362308189,"score_gpt":0.4873701892797131,"score_spread":0.3995250530488942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}