{"id":"W2741869046","doi":"10.1158/1538-7445.am2017-ct038","title":"Abstract CT038: A phase I, open-label, dose-escalation study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of GSK3326595 in subjects with solid tumors and non-Hodgkin's lymphoma","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Pharmacodynamics; Pharmacokinetics; Pharmacology; Lymphoma; Oncology; Toxicity; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269707,0.001340592,0.001838222,0.0005664569,0.0004363138,0.0006901129,0.0009943087,0.001116498,0.005425212],"category_scores_gemma":[0.0007209294,0.000515777,0.0009537748,0.0006222889,0.0008475496,0.0006827718,0.0002843631,0.003368422,0.001409646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132742,"about_ca_system_score_gemma":0.001875213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123697,"about_ca_topic_score_gemma":0.003469999,"domain_scores_codex":[0.9995889,0.0001632392,0.00002434246,0.00007570172,0.0000571505,0.00009061009],"domain_scores_gemma":[0.9991845,0.00009630089,0.0001467667,0.00006345354,0.00007089549,0.0004381013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5087907,0.1598695,0.01116099,0.00135989,0.00133392,0.0008345479,0.0003957531,0.003131918,0.1940136,0.0004801438,0.01100283,0.1076262],"study_design_scores_gemma":[0.3137701,0.6582139,0.01272507,0.00003827431,0.0003701949,0.0004670798,0.00006761208,0.001264404,0.009045529,0.0002148257,0.003789023,0.00003396907],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888216,0.0013995,0.0008482916,0.0004338978,0.0001100696,0.003785062,0.002547134,0.0002468297,0.001807483],"genre_scores_gemma":[0.9815616,0.001000047,0.00259781,0.001132124,0.0001226717,0.004917827,0.003877396,0.00005077347,0.00473977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005425212,"threshold_uncertainty_score":0.01814914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0878451362308189,"score_gpt":0.4873701892797131,"score_spread":0.3995250530488942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}