{"id":"W2741973413","doi":"10.1158/1538-7445.am2017-4349","title":"Abstract 4349: Adverse & anticancer activities of 5-azaCdR & DNA methyltransferase (DNMT) isoform specific inhibitors: therapeutic implications","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"DNMT1; DNA methylation; Methyltransferase; Biology; DNA methyltransferase; Cancer research; Carcinogenesis; Epigenetics; Transcriptome; Gene isoform; Methylation; Gene expression; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001569129,0.0003726835,0.0003674899,0.0002911232,0.0001295781,0.000291819,0.000235243,0.0003375901,0.004509617],"category_scores_gemma":[0.00009576577,0.0001170521,0.000215591,0.0002792128,0.0001267961,0.0001623878,0.0001445472,0.0007374837,0.0009568275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000319772,"about_ca_system_score_gemma":0.0002252481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004094579,"about_ca_topic_score_gemma":0.0008805526,"domain_scores_codex":[0.9999092,0.00001628205,0.00000864918,0.00001778363,0.00003104049,0.000017012],"domain_scores_gemma":[0.9999415,0.000009123008,0.00001709621,0.000006390344,0.0000138536,0.00001209247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004436866,0.0001414705,0.0003284623,0.0003439342,0.00002882962,0.0001327094,0.00001586303,0.000309937,0.9706118,0.0005426924,0.001302108,0.02579864],"study_design_scores_gemma":[0.0000944331,0.001906405,0.0065236,0.00004259804,0.00009640644,0.0009683446,0.00002016823,0.0008498874,0.9439008,0.0002817161,0.0453031,0.00001248113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7854567,0.1620813,0.012563,0.002637751,0.0007558616,0.0002927957,0.006258271,0.0008403337,0.02911396],"genre_scores_gemma":[0.9448496,0.03026037,0.005708536,0.0005537582,0.0001488431,0.0001176252,0.003675132,0.00006768485,0.01461846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004509617,"threshold_uncertainty_score":0.01508623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1227768489154888,"score_gpt":0.4284923054907416,"score_spread":0.3057154565752528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}