{"id":"W2741989542","doi":"10.3390/ijms18081679","title":"Do Multiwell Plate High Throughput Assays Measure Loss of Cell Viability Following Exposure to Genotoxic Agents?","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Formazan; Viability assay; Cytotoxicity; Cell culture; Plate reader; Cisplatin; Biology; Microtiter plate; Cell growth; MTT assay; Radiosensitivity; High-content screening; High-throughput screening; Neutral red; Chemosensitivity assay; Gentamicin protection assay; Cell; Chemistry; Molecular biology; Biochemistry; In vitro; Chemotherapy; Fluorescence; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01511839,0.00325646,0.00515253,0.002704152,0.0008127491,0.005346911,0.00359195,0.005237788,0.003523193],"category_scores_gemma":[0.01815426,0.001954821,0.001282152,0.004318762,0.002421403,0.005706421,0.001433516,0.00472965,0.0062558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127845,"about_ca_system_score_gemma":0.0007768991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223607,"about_ca_topic_score_gemma":0.002827039,"domain_scores_codex":[0.9711598,0.007550707,0.002359999,0.004372105,0.01319102,0.001366507],"domain_scores_gemma":[0.9716641,0.01040259,0.006188243,0.003131968,0.008051418,0.0005616651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001400717,0.001785598,0.04819458,0.009859265,0.001161366,0.0005773501,0.00192115,0.001331529,0.8075835,0.004713344,0.02796563,0.09350601],"study_design_scores_gemma":[0.0001123247,0.002260538,0.04403999,0.000726153,0.0007365514,0.002261836,0.001247214,0.006289579,0.8545129,0.004816057,0.08262417,0.0003726422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1833812,0.1193968,0.6162606,0.02044762,0.01476972,0.001794353,0.01262403,0.007909234,0.02341635],"genre_scores_gemma":[0.5240864,0.09595459,0.3070789,0.01605072,0.004978494,0.004465224,0.02111166,0.001832291,0.02444167],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01511839,"threshold_uncertainty_score":0.07995462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02498535445128991,"score_gpt":0.3282532494237799,"score_spread":0.30326789497249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}