{"id":"W2742029328","doi":"10.1073/pnas.1706981114","title":"Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Shastri Indo-Canadian Institute","keywords":"Nucleotide excision repair; Xeroderma pigmentosum; DNA repair; DNA damage; Biology; Context (archaeology); PARP1; XRCC1; Molecular biology; Chemistry; DNA; Cell biology; Polymerase; Biochemistry; Poly ADP ribose polymerase; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646625,0.0003326962,0.000323887,0.0001661671,0.0002269025,0.0005449838,0.0001975686,0.0004184028,0.001206097],"category_scores_gemma":[0.0001956967,0.0002081983,0.0001778107,0.000141442,0.0001752686,0.000358438,0.000312552,0.0006052222,0.0007161638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130337,"about_ca_system_score_gemma":0.0001523006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002875128,"about_ca_topic_score_gemma":0.0003056597,"domain_scores_codex":[0.9997528,0.00002741536,0.00001845459,0.00009199329,0.00007543722,0.00003383176],"domain_scores_gemma":[0.9998951,0.00001590664,0.00003077824,0.00002008471,0.00001578561,0.0000224452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005110474,0.00002203309,0.0003978942,0.0000414322,0.000005274636,0.00007631144,0.00001725302,0.00008225071,0.9973851,0.00007784549,0.00006012325,0.001783396],"study_design_scores_gemma":[0.00000461335,0.00007994667,0.01005014,0.000007812803,0.000008902969,0.0003814422,0.00001854636,0.001214695,0.9852985,0.00005221449,0.002877661,0.000005510278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834848,0.005893349,0.007851668,0.0001441203,0.00006239544,0.00003893585,0.0003976448,0.0001925215,0.001934586],"genre_scores_gemma":[0.9885612,0.00185315,0.002957182,0.00007768404,0.00001802241,0.00003717689,0.0009053034,0.00004670709,0.005543622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206097,"threshold_uncertainty_score":0.004034817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03458474833536972,"score_gpt":0.3124781615943057,"score_spread":0.277893413258936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}