{"id":"W2742086441","doi":"10.1038/s41467-017-00174-7","title":"Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Meningioma; Biology; Cancer research; Exome; Exome sequencing; Radiation therapy; DNA methylation; Gene; Genetics; Medicine; Pathology; Mutation; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516722,0.00009029763,0.000185513,0.0001185883,0.0005042692,0.00004243509,0.0005476943,0.000124129,0.00002172974],"category_scores_gemma":[0.0001660287,0.00008055545,0.00008027504,0.0000974781,0.0001028843,0.0001412903,0.0001102213,0.0002842663,8.008875e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005200088,"about_ca_system_score_gemma":0.00007536407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009980242,"about_ca_topic_score_gemma":0.0004760285,"domain_scores_codex":[0.9993521,0.00003726465,0.0002386292,0.0001298354,0.0001196464,0.0001225419],"domain_scores_gemma":[0.9979795,0.00009992305,0.0002267711,0.001535565,0.0001211161,0.00003715009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002695427,0.0008880781,0.5319158,0.0002594756,0.001230876,0.000008884663,0.01197025,0.0001682392,0.02080333,0.3312895,0.007526353,0.09366962],"study_design_scores_gemma":[0.001303218,0.00006054799,0.9865679,0.00007635562,0.0001323878,0.000006264053,0.0001505473,0.003144183,0.0009155417,0.001799898,0.005746967,0.00009619114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463099,0.01550043,0.0002675375,0.02445764,0.0003834759,0.00186786,0.00007262293,0.00005219771,0.01108832],"genre_scores_gemma":[0.9933124,0.0001478341,0.005717359,0.00008441861,0.00005103078,0.0001945385,0.0001238173,0.00001250223,0.0003561031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4546521,"threshold_uncertainty_score":0.3878482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03711030644167153,"score_gpt":0.3807034559222557,"score_spread":0.3435931494805842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}