{"id":"W2742102900","doi":"10.1158/1538-7445.am2017-ct047","title":"Abstract CT047: Phase 1 dose-escalation study of the CDK inhibitor dinaciclib in combination with the PARP inhibitor veliparib in patients with advanced solid tumors","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Veliparib; PARP inhibitor; Medicine; Neutropenia; Febrile neutropenia; Mucositis; Internal medicine; Oncology; Nausea; Pharmacology; Chemotherapy; Poly ADP ribose polymerase; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007318069,0.0002030958,0.0003781873,0.0002075316,0.0003759463,0.00005668284,0.000432634,0.00006341492,0.00002947219],"category_scores_gemma":[0.0001777074,0.0001095666,0.00003161278,0.000567258,0.0005545454,0.0004525109,0.0001430215,0.0008058271,0.000002426154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006036671,"about_ca_system_score_gemma":0.0003875728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000819723,"about_ca_topic_score_gemma":0.003080738,"domain_scores_codex":[0.9972517,0.0001709726,0.0003842574,0.0004198634,0.001298471,0.0004747695],"domain_scores_gemma":[0.9979058,0.000134938,0.0003398741,0.0009430808,0.0005894384,0.00008685298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01627664,0.004503988,0.8973666,0.0001506874,0.00007384797,0.00002216059,0.005303443,0.0008040093,0.009312685,0.00002950403,0.00005166814,0.06610481],"study_design_scores_gemma":[0.02835457,0.002464338,0.9550812,0.000928075,0.00001594771,8.666835e-7,0.002143552,0.00004624299,0.01064652,0.00004950664,0.0001370452,0.000132161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949269,0.0001091747,0.000005705046,0.001457284,0.0001068118,0.003235972,0.00001725655,0.00001418554,0.0001266865],"genre_scores_gemma":[0.9990239,0.00001261427,0.00002118945,0.00003075683,0.0001025455,0.000673059,0.000009064618,0.0000452619,0.0000816231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06597265,"threshold_uncertainty_score":0.4467996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04430193968758227,"score_gpt":0.4081689631978827,"score_spread":0.3638670235103004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}