{"id":"W2742123929","doi":"10.1245/s10434-017-5926-z","title":"Nonoperative Management for Invasive Breast Cancer After Neoadjuvant Systemic Therapy: Conceptual Basis and Fundamental International Feasibility Clinical Trials","year":2017,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; University of Birmingham","keywords":"Medicine; Breast cancer; Neoadjuvant therapy; Surgical oncology; Clinical trial; Systemic therapy; Percutaneous; Biopsy; Radiology; Breast surgery; Gold standard (test); Cancer; Surgery; Medical physics; General surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01137236,0.0005042765,0.0007912846,0.0002970777,0.0005326663,0.001169895,0.0007074798,0.0007010385,0.002871225],"category_scores_gemma":[0.008731134,0.0001865739,0.0005371338,0.0007939349,0.003170922,0.001401715,0.0007138372,0.0018221,0.0003311321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008985526,"about_ca_system_score_gemma":0.00236147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005948719,"about_ca_topic_score_gemma":0.0009227721,"domain_scores_codex":[0.9952884,0.003921781,0.0001819304,0.0002021755,0.0002020024,0.0002037689],"domain_scores_gemma":[0.9931023,0.004355637,0.0009866299,0.0007611035,0.0003327696,0.0004615674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2426169,0.04557887,0.05845014,0.002353845,0.001110259,0.0001975111,0.001015019,0.001735718,0.01562079,0.0151091,0.00241345,0.6137984],"study_design_scores_gemma":[0.07892922,0.6466892,0.1630318,0.003310543,0.003667164,0.001070345,0.004161512,0.003184564,0.02123423,0.01853091,0.05601701,0.0001736096],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208928,0.04348064,0.004269436,0.006263059,0.0005244034,0.002291196,0.0003513537,0.00002109516,0.02190592],"genre_scores_gemma":[0.9779929,0.01435282,0.003603615,0.0009833333,0.000601251,0.001175647,0.0003296905,0.00001002633,0.0009508125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01137236,"threshold_uncertainty_score":0.06014347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2278568102726611,"score_gpt":0.4932497454024546,"score_spread":0.2653929351297936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}