{"id":"W2742169549","doi":"10.1182/blood.v128.22.3318.3318","title":"An Open-Label, Single-Arm, Phase 1 Study of the Pharmacokinetics (PK) and Safety of Carfilzomib in Patients with Relapsed Multiple Myeloma and End-Stage Renal Disease (ESRD)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Carfilzomib; Medicine; Pharmacokinetics; Hemodialysis; Cmax; Renal function; Urology; End stage renal disease; Multiple myeloma; Internal medicine; Gastroenterology; Proteasome inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001662149,0.001435389,0.002658298,0.0003767533,0.0005442911,0.0009713771,0.0009236016,0.00118897,0.003588504],"category_scores_gemma":[0.001381136,0.0007360454,0.001100977,0.0004317041,0.00113978,0.001304195,0.0004200235,0.003758485,0.0008014491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075361,"about_ca_system_score_gemma":0.001840802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007390723,"about_ca_topic_score_gemma":0.001582213,"domain_scores_codex":[0.9993197,0.0002901233,0.00002793038,0.0001637742,0.00008306199,0.0001155766],"domain_scores_gemma":[0.9987974,0.0001947736,0.0002627165,0.0001227361,0.00007324352,0.0005492201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7961488,0.1159134,0.008512904,0.0003834484,0.0007135123,0.0001697292,0.0002922683,0.001684602,0.03512102,0.0001270875,0.001394342,0.03953893],"study_design_scores_gemma":[0.3311051,0.6443304,0.0187048,0.00001175935,0.0002289647,0.0001917475,0.0000489415,0.001380865,0.00266872,0.00009675688,0.001206667,0.00002531163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969694,0.0004635305,0.0003562563,0.0001344763,0.00004627498,0.001099964,0.000387664,0.00005301538,0.0004894796],"genre_scores_gemma":[0.9942178,0.0003187315,0.001196534,0.0003514543,0.0001302,0.001726288,0.0007387943,0.00001792706,0.001302346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003588504,"threshold_uncertainty_score":0.01200473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03127264767840359,"score_gpt":0.3132466429932698,"score_spread":0.2819739953148662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}