{"id":"W2742358131","doi":"10.1371/journal.ppat.1006553","title":"Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Western Canada Research Grid; Genome Alberta; Canada Research Chairs; Alberta Agriculture and Forestry; Compute Canada; Genome Canada; University of Calgary","keywords":"Infectivity; Chronic wasting disease; Prion protein; Biology; Recombinant DNA; In vitro; Virology; Protein folding; Protein structure; In vivo; Phenotype; Gene; Cell biology; Genetics; Scrapie; Virus; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095916,0.0002278738,0.0001817646,0.0001889086,0.0001625154,0.0003483858,0.0002006976,0.0002443059,0.0009678837],"category_scores_gemma":[0.0004948249,0.0001452193,0.0002250154,0.0001337545,0.0002451747,0.0002364914,0.0002069802,0.000375741,0.0002288551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845598,"about_ca_system_score_gemma":0.0001679745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600978,"about_ca_topic_score_gemma":0.001520438,"domain_scores_codex":[0.9999276,0.000009847306,0.000006494969,0.00002118562,0.00002027547,0.00001465751],"domain_scores_gemma":[0.999844,0.00004517294,0.00004325198,0.000009315316,0.00002059893,0.00003765503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003085324,0.00005266043,0.00670237,0.00008524179,0.00003541231,0.000221396,0.00007986151,0.002094074,0.9869466,0.0004388376,0.0001146029,0.002920427],"study_design_scores_gemma":[0.00007443169,0.0009108892,0.1247587,0.00009303668,0.0002381219,0.001452614,0.0002571982,0.04673601,0.8208659,0.0009177531,0.003590433,0.0001048544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998549,0.0004089318,0.0003758033,0.00001581488,0.000007041106,0.000005700756,0.00005947824,0.00001226024,0.0005658702],"genre_scores_gemma":[0.9990319,0.0001992863,0.0004107213,0.00001077293,0.000002043086,0.000005307712,0.000133301,0.00000807976,0.0001986245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600978,"threshold_uncertainty_score":0.003237903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283358104765722,"score_gpt":0.2537439528523515,"score_spread":0.2309103718046943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}