{"id":"W2742358131","doi":"10.1371/journal.ppat.1006553","title":"Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Western Canada Research Grid; Genome Alberta; Canada Research Chairs; Alberta Agriculture and Forestry; Compute Canada; Genome Canada; University of Calgary","keywords":"Infectivity; Chronic wasting disease; Prion protein; Biology; Recombinant DNA; In vitro; Virology; Protein folding; Protein structure; In vivo; Phenotype; Gene; Cell biology; Genetics; Scrapie; Virus; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168417,0.0001474399,0.0001330106,0.00005725694,0.0002900194,0.00005599492,0.0001871155,0.0001275852,0.00001430152],"category_scores_gemma":[0.0001749657,0.0001429564,0.00004993362,0.00003273712,0.0000837202,0.00002304614,0.00019757,0.00006962308,0.000006593009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002176116,"about_ca_system_score_gemma":0.00005068836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002597917,"about_ca_topic_score_gemma":0.00001773246,"domain_scores_codex":[0.9991102,0.00003701688,0.0002074046,0.0002945381,0.0001270144,0.0002238256],"domain_scores_gemma":[0.9992675,0.000007290584,0.0001849452,0.0004017429,0.0000476118,0.00009094415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006994204,0.000044498,0.01723082,0.00009313684,0.000005444713,0.000009180776,0.00009737704,0.000004518202,0.9659531,0.00001069531,0.000004579051,0.01647676],"study_design_scores_gemma":[0.001444593,0.0003082918,0.05425983,0.0002798919,0.00003196112,0.00002121703,0.0001142762,0.004734484,0.9372766,0.000118362,0.0009940158,0.0004165038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967472,0.002347955,0.00008654386,0.00007578311,0.00005302564,0.000576004,0.00001796307,0.00001391917,0.00008161784],"genre_scores_gemma":[0.9984103,0.001016035,0.00033431,0.00004688838,0.00006297394,0.00004084222,0.00004724847,0.00001573301,0.00002565325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03702901,"threshold_uncertainty_score":0.5829593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283358104765722,"score_gpt":0.2537439528523515,"score_spread":0.2309103718046943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}