{"id":"W2742485798","doi":"10.1038/s41598-017-07947-6","title":"Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Cancer cell; Hypoxia (environmental); Retinoblastoma protein; Actin cytoskeleton; Retinoblastoma; Motility; Chemistry; LNCaP; MAPK/ERK pathway; Kinase; Cancer research; Signal transduction; Biology; Cell; Cytoskeleton; Cancer; Cell cycle; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104397,0.0001364199,0.00009002876,0.0001510409,0.0001558493,0.0001390999,0.0001117633,0.0001227783,0.0007107476],"category_scores_gemma":[0.0001256235,0.0001194234,0.00009905227,0.000126268,0.00022958,0.000126944,0.0001398769,0.0002597173,0.0001344827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023622,"about_ca_system_score_gemma":0.000113057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00152318,"about_ca_topic_score_gemma":0.002551502,"domain_scores_codex":[0.9999272,0.00001187163,0.000004367555,0.00001221656,0.00002777431,0.00001659797],"domain_scores_gemma":[0.9999254,0.00001771049,0.00003155976,0.000007063329,0.000008150522,0.00001014086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002252873,0.000004272803,0.0001506749,0.000006536432,0.000001434441,0.000008440962,0.000008074726,0.00003782392,0.9993659,0.0000178701,0.00001019375,0.0003663605],"study_design_scores_gemma":[0.00000310651,0.00006965867,0.006577445,0.00000119315,0.000004397092,0.00005940135,0.00002216679,0.0007394437,0.9920552,0.00001753237,0.0004478969,0.000002599205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954708,0.0004971854,0.003281635,0.00007652632,0.000008801278,0.0000075711,0.0001019999,0.00004106402,0.0005145622],"genre_scores_gemma":[0.9960294,0.0004889918,0.002021853,0.00002500155,0.000003731576,0.00001613101,0.0001116996,0.000009585659,0.001293691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152318,"threshold_uncertainty_score":0.003028691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391608617129344,"score_gpt":0.2762071548686906,"score_spread":0.2522910686973972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}