{"id":"W2742491306","doi":"10.1101/171488","title":"Role of KCC2-Dependent Potassium Efflux in 4-Aminopyridine-Induced Epileptiform Synchronization","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Inhibitory postsynaptic potential; Neuroscience; Interneuron; GABAA receptor; 4-Aminopyridine; Stimulation; Ictal; Chemistry; Optogenetics; Excitatory postsynaptic potential; Dravet syndrome; Biology; Potassium channel; Epilepsy; Receptor; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007527505,0.0002827734,0.0002777843,0.0001114043,0.0001378724,0.0003107607,0.0002397909,0.0002147591,0.000438121],"category_scores_gemma":[0.0001567028,0.0001233782,0.0002133348,0.00007660889,0.0002303042,0.000334025,0.0002772525,0.0002321424,0.00008867047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005134062,"about_ca_system_score_gemma":0.0002703283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002024698,"about_ca_topic_score_gemma":0.001646205,"domain_scores_codex":[0.9999537,0.000008667037,0.000004993168,0.00001011852,0.000009719739,0.00001270816],"domain_scores_gemma":[0.9999444,0.000009232106,0.00001983419,0.000005826516,0.000009495235,0.00001120474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788922,0.00003329674,0.002054843,0.0001101303,0.00002173301,0.0003366757,0.00003620758,0.02648797,0.9661822,0.002879695,0.00007250544,0.001605927],"study_design_scores_gemma":[0.00008436368,0.0002469988,0.01293807,0.00001819504,0.00005752977,0.0005181681,0.00008984921,0.5347152,0.4472054,0.002087801,0.001998334,0.00004012462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842513,0.00062117,0.0129661,0.0001422356,0.00001242161,0.00001734333,0.0001114431,0.0001283305,0.001749658],"genre_scores_gemma":[0.9989185,0.0001701793,0.0006184366,0.000006807644,0.000001210386,0.000005410158,0.00003301647,0.000006843595,0.0002395417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002024698,"threshold_uncertainty_score":0.004025877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0333682642621136,"score_gpt":0.2890967700657491,"score_spread":0.2557285058036355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}