{"id":"W2742495557","doi":"10.2196/resprot.8001","title":"Combination Analgesic Development for Enhanced Clinical Efficacy (CADENCE Trial): Study Protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of an Alpha-Lipoic Acid – Pregabalin Combination for the Treatment of Fibromyalgia Pain","year":2017,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Queen's University","keywords":"Pregabalin; Medicine; Analgesic; Crossover study; Placebo; Clinical trial; Cadence; Randomized controlled trial; Physical therapy; Fibromyalgia; Double blind; Anesthesia; Pharmacology; Physical medicine and rehabilitation; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01586427,0.006129029,0.007803862,0.001447795,0.002803991,0.002972009,0.00375076,0.007438248,0.05286287],"category_scores_gemma":[0.01234271,0.002628174,0.003642645,0.001568057,0.00353197,0.003555397,0.001729496,0.007443932,0.01108323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002613076,"about_ca_system_score_gemma":0.008687653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001669791,"about_ca_topic_score_gemma":0.003841193,"domain_scores_codex":[0.9910875,0.004743554,0.0006965916,0.001140633,0.0009556706,0.001376018],"domain_scores_gemma":[0.9936203,0.001193633,0.001444812,0.0009425722,0.0009207156,0.001877891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9757814,0.01252241,0.0001895007,0.001452885,0.0004037192,0.00004791537,0.000060151,0.0002618441,0.00108903,0.0004739568,0.002991129,0.004726145],"study_design_scores_gemma":[0.979498,0.01729549,0.0002913265,0.00006438528,0.0001204972,0.0000094325,0.000008428316,0.0001483941,0.0001170015,0.0002494384,0.002183135,0.00001442357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02811908,0.0009141418,0.001887729,0.0008239294,0.000963294,0.9589856,0.00427027,0.0002572963,0.003778665],"genre_scores_gemma":[0.02595166,0.0005045349,0.00369146,0.001044538,0.0003433455,0.9648914,0.00112914,0.00002113275,0.002422785],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05286287,"threshold_uncertainty_score":0.1768439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3440145610966535,"score_gpt":0.5931059338660377,"score_spread":0.2490913727693842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}