{"id":"W2742550673","doi":"10.1016/j.stem.2017.07.003","title":"Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations","year":2017,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":464,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; York University; University of Toronto; University of British Columbia; University Health Network","funders":"Department of Medical Biophysics, University of Toronto; Canadian Institutes of Health Research","keywords":"Mesoderm; Induced pluripotent stem cell; Biology; Retinoic acid; NODAL; Cell biology; Lateral plate mesoderm; Stem cell; Nodal signaling; Internal medicine; Embryonic stem cell; Anatomy; Embryogenesis; Embryo; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003425513,0.0002184717,0.0001538611,0.0003150216,0.0001429569,0.0004731939,0.0001816055,0.0002137287,0.00106564],"category_scores_gemma":[0.0002157788,0.0002126478,0.0001938339,0.0001537555,0.0001810414,0.0002642648,0.0002973855,0.0005418218,0.0005634774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001183262,"about_ca_system_score_gemma":0.0001430355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551094,"about_ca_topic_score_gemma":0.000360725,"domain_scores_codex":[0.9998811,0.00002395914,0.00002234767,0.00002221065,0.00003549633,0.00001486363],"domain_scores_gemma":[0.9998355,0.00004697991,0.00003386484,0.00001859999,0.00002756907,0.0000375682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001065498,0.000008420639,0.0008695836,0.00002850516,0.000008792027,0.000102555,0.00005298985,0.00004628041,0.9941116,0.001286018,0.0000613372,0.003317301],"study_design_scores_gemma":[0.00007833476,0.0002881853,0.03087071,0.00003552638,0.00008988486,0.001950922,0.0001572804,0.0009851413,0.954005,0.0008579692,0.01066614,0.00001493936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952235,0.004459381,0.03002647,0.0002576129,0.0001045158,0.0000886468,0.001340401,0.0001106892,0.01137721],"genre_scores_gemma":[0.9795961,0.001909647,0.009521555,0.0001663145,0.00005050141,0.00006091052,0.002029738,0.0000581251,0.006607142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106564,"threshold_uncertainty_score":0.003564954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02934115958727,"score_gpt":0.2759127695979948,"score_spread":0.2465716100107248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}