{"id":"W2742580821","doi":"10.1172/jci87406","title":"Epiregulin and EGFR interactions are involved in pain processing","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; University of Toronto","funders":"National Institute of Dental and Craniofacial Research; National Institute on Aging; Canadian Pain Society; National Health and Medical Research Council; Canadian Institutes of Health Research; University at Buffalo; University of North Carolina at Chapel Hill; National Institutes of Health; Louise and Alan Edwards Foundation; McGill University; Emory University; Medical Research Council; Battelle","keywords":"Epiregulin; Epidermal growth factor receptor; PI3K/AKT/mTOR pathway; Chronic pain; Cancer research; Protein kinase B; Receptor tyrosine kinase; Tyrosine kinase; Receptor; Medicine; Chemistry; Signal transduction; Cell biology; Biology; Neuroscience; Internal medicine; Amphiregulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241981,0.0002929927,0.0002382869,0.0001945516,0.0001369923,0.0003121334,0.0001353279,0.0002847388,0.001391913],"category_scores_gemma":[0.000097342,0.0001036228,0.0002287995,0.0001274247,0.0001765146,0.0002310432,0.0001817081,0.0004954486,0.0002930799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411468,"about_ca_system_score_gemma":0.0001366807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003082752,"about_ca_topic_score_gemma":0.0005709224,"domain_scores_codex":[0.9998537,0.00002956275,0.000006411569,0.00002618887,0.00003105269,0.00005296198],"domain_scores_gemma":[0.9999567,0.00000500076,0.00001860543,0.000003307687,0.000005477457,0.00001089219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000351089,0.00004302911,0.001308555,0.00009129311,0.00002670653,0.0003862113,0.00002530883,0.0001383798,0.9875132,0.0004826217,0.00008513495,0.009548427],"study_design_scores_gemma":[0.00004324181,0.0007916113,0.1110619,0.00003261517,0.0001547309,0.002892759,0.0001358822,0.001243495,0.8693849,0.0005908938,0.01364675,0.00002125182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738052,0.01968955,0.00257926,0.0002267994,0.00003661683,0.0000228146,0.000211912,0.00005382418,0.003374052],"genre_scores_gemma":[0.9925995,0.003650601,0.001018691,0.0001001851,0.00001447945,0.00001270447,0.0001744952,0.00000588405,0.002423434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391913,"threshold_uncertainty_score":0.004656434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1802133457176293,"score_gpt":0.4424194082111994,"score_spread":0.2622060624935701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}