{"id":"W2742791156","doi":"10.1016/j.bbmt.2017.07.022","title":"GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation","year":2017,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Busulfan; Dosing; Hematopoietic stem cell transplantation; Conditioning regimen; Transplantation; Internal medicine; Regimen; Pharmacogenetics; Fludarabine; Oncology; Chemotherapy; Cyclophosphamide; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004530999,0.0003257798,0.00083983,0.0004767694,0.0002563799,0.001067866,0.0006442987,0.0006393885,0.001311727],"category_scores_gemma":[0.01410164,0.0002059071,0.0005697884,0.0007324545,0.0004928419,0.001044998,0.0004160778,0.001865519,0.0003043851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144319,"about_ca_system_score_gemma":0.002357231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002951959,"about_ca_topic_score_gemma":0.005034482,"domain_scores_codex":[0.9972751,0.001234734,0.0005012741,0.0002295959,0.0006346926,0.0001246771],"domain_scores_gemma":[0.994052,0.003144296,0.001338451,0.0002902186,0.0008372492,0.0003378559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002442703,0.0003204189,0.3588588,0.0009954146,0.001400917,0.0006536202,0.0006041552,0.005942098,0.00756197,0.01019482,0.02741779,0.5836073],"study_design_scores_gemma":[0.0006539154,0.002278153,0.73581,0.003217159,0.005398953,0.004639509,0.001675955,0.0244207,0.02064692,0.03585346,0.1652121,0.0001932096],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6925082,0.1565273,0.03342168,0.09818397,0.002326109,0.0001911872,0.001769231,0.0004043692,0.01466798],"genre_scores_gemma":[0.9644077,0.01755426,0.01145803,0.004108073,0.0008349241,0.00005431859,0.0007733587,0.0000943278,0.0007150428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004530999,"threshold_uncertainty_score":0.0239625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688642376974692,"score_gpt":0.2811648007280858,"score_spread":0.2542783769583389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}