{"id":"W2742850121","doi":"10.1139/bcb-2017-0147","title":"MeCP2 and CTCF: enhancing the cross-talk of silencers","year":2017,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"CTCF; MECP2; Chromatin; Rett syndrome; Biology; Computational biology; Genetics; Gene; Insulator (electricity); Transcription factor; Neuroscience; Cell biology; Enhancer; Phenotype; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892905,0.0003371009,0.0005594586,0.00002096167,0.0001928761,0.00003573251,0.000395105,0.0005464595,0.00001303873],"category_scores_gemma":[0.00006582552,0.000237378,0.0001623193,0.00003096514,0.0006810473,0.000001463667,0.0004165202,0.0001651965,0.000001640015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005672845,"about_ca_system_score_gemma":0.0001709117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001090009,"about_ca_topic_score_gemma":0.000004142461,"domain_scores_codex":[0.9986771,0.00005883456,0.0003804039,0.0005812317,0.00005230799,0.0002500717],"domain_scores_gemma":[0.9989665,0.00003332015,0.0003766528,0.0005105783,0.00003585197,0.00007708748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002087255,0.00003886788,0.00007215369,0.006545037,0.0001486218,0.000002995916,0.00002373225,1.910557e-7,0.5261465,0.00001597449,0.0002073641,0.4667777],"study_design_scores_gemma":[0.0001758187,0.0001050448,0.00004527936,0.0003227426,0.0001103866,0.00003851123,0.0000318118,3.872442e-7,0.1618231,0.00002228269,0.8370209,0.0003037992],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04112814,0.9564672,0.000005243115,0.00001077367,0.0001311794,0.0001927164,0.00008697429,0.000003488838,0.001974275],"genre_scores_gemma":[0.07661343,0.9218992,0.00004244266,0.00003084191,0.00005805177,0.00002910757,0.0002212244,0.00002213243,0.001083552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8368135,"threshold_uncertainty_score":0.9679995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373753884973303,"score_gpt":0.308889095817978,"score_spread":0.285151556968245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}