{"id":"W2742850121","doi":"10.1139/bcb-2017-0147","title":"MeCP2 and CTCF: enhancing the cross-talk of silencers","year":2017,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"CTCF; MECP2; Chromatin; Rett syndrome; Biology; Computational biology; Genetics; Gene; Insulator (electricity); Transcription factor; Neuroscience; Cell biology; Enhancer; Phenotype; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003444712,0.0007231509,0.0009187558,0.001665551,0.0001937931,0.000807324,0.000758853,0.001020266,0.002437661],"category_scores_gemma":[0.0003511783,0.0002253104,0.0002997689,0.001168563,0.0003546707,0.0008974509,0.0006755029,0.001083401,0.001692497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005611666,"about_ca_system_score_gemma":0.0004639938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006190865,"about_ca_topic_score_gemma":0.0008846405,"domain_scores_codex":[0.9998701,0.00001783902,0.00001735221,0.0000280332,0.00004820487,0.0000184824],"domain_scores_gemma":[0.999869,0.00006550555,0.0000208012,0.000004498129,0.00002463588,0.00001542209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008550116,0.0000578909,0.0002082847,0.01237177,0.00009334135,0.0004891406,0.00008303487,0.0004665038,0.01622441,0.008246399,0.01325534,0.9484185],"study_design_scores_gemma":[0.00001069655,0.00007463719,0.0005202613,0.001032079,0.00006053406,0.001614884,0.00003779522,0.00009106091,0.006093159,0.00146701,0.9889784,0.00001939008],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003383483,0.9971092,0.0003435061,0.0001886159,0.0001570491,0.000005777176,0.0000216724,0.00001236565,0.001823399],"genre_scores_gemma":[0.002099608,0.9953642,0.0004403697,0.0001910032,0.0001596908,0.00001374368,0.00005449179,0.000004329056,0.001672573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002437661,"threshold_uncertainty_score":0.00815475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373753884973303,"score_gpt":0.308889095817978,"score_spread":0.285151556968245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}