{"id":"W2742893306","doi":"10.1038/s41467-017-02760-1","title":"BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Genome instability; Bloom syndrome; Genetics; Biology; Gene; Helicase; Genome; Sister chromatid exchange; RecQ helicase; DNA; DNA repair; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581116,0.0002404789,0.0002201474,0.000256298,0.0001148244,0.0003030502,0.0001925425,0.0003337195,0.001116993],"category_scores_gemma":[0.0002006379,0.000138003,0.0001441508,0.0001162379,0.000207895,0.00008822556,0.0002081155,0.0003583427,0.0003834848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754277,"about_ca_system_score_gemma":0.0001823793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004813133,"about_ca_topic_score_gemma":0.0008448392,"domain_scores_codex":[0.9998646,0.00002576803,0.00001302702,0.00003982803,0.00003141116,0.00002539768],"domain_scores_gemma":[0.9998134,0.00005115231,0.00005733882,0.00003027061,0.00001109157,0.00003680971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002892147,0.000004296116,0.00006710465,0.000007676446,0.000001148127,0.00001575531,0.000003202697,0.00002911855,0.9993999,0.00002525264,0.00001230499,0.0004052938],"study_design_scores_gemma":[0.000008500334,0.0000588832,0.001445488,0.000002421987,0.000003993597,0.00008402667,0.000006601128,0.0006422364,0.9965103,0.00003370962,0.001202315,0.00000136602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994222,0.0005281438,0.003377219,0.0000994199,0.00002001686,0.00001381846,0.0003929674,0.0002900806,0.001056373],"genre_scores_gemma":[0.9955559,0.000147383,0.002288306,0.00004293322,0.000004988419,0.000008778474,0.000346615,0.00004943299,0.001555631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116993,"threshold_uncertainty_score":0.003736734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415602673777318,"score_gpt":0.3421543718326384,"score_spread":0.3279983450948652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}