{"id":"W2742893306","doi":"10.1038/s41467-017-02760-1","title":"BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Genome instability; Bloom syndrome; Genetics; Biology; Gene; Helicase; Genome; Sister chromatid exchange; RecQ helicase; DNA; DNA repair; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201934,0.0001041741,0.00008566805,0.00006475287,0.0001276411,0.00001443699,0.0004950258,0.000242088,0.00003250543],"category_scores_gemma":[0.00008947535,0.0001104869,0.00004930805,0.0001598529,0.00009425596,0.000003994723,0.0001912275,0.0002027959,0.0000150352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002273941,"about_ca_system_score_gemma":0.00002253658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001893911,"about_ca_topic_score_gemma":0.00262221,"domain_scores_codex":[0.9993615,0.00006087026,0.0001621976,0.000193046,0.00007055482,0.0001518086],"domain_scores_gemma":[0.9987164,0.00002956288,0.00002980276,0.001069647,0.0001102658,0.00004431518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002801696,0.000134076,0.003006273,0.00001224215,0.00002360661,6.743315e-7,0.0002418125,0.00008435347,0.9876971,0.0005085355,0.003975449,0.004287826],"study_design_scores_gemma":[0.0006001716,0.0001136177,0.01797564,0.00001858144,0.00001746172,0.00001743687,0.00007922215,0.001425079,0.6562176,0.00009261675,0.3232051,0.0002373804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722694,0.01963652,0.00167932,0.002630305,0.0002741057,0.0002929808,0.00004531513,0.00004149099,0.003130637],"genre_scores_gemma":[0.9939902,0.001755323,0.003226598,0.0001769114,0.00009209335,0.00003827135,0.0003708329,0.00001776253,0.000331949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3314795,"threshold_uncertainty_score":0.4505525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415602673777318,"score_gpt":0.3421543718326384,"score_spread":0.3279983450948652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}