{"id":"W2743093337","doi":"10.1016/j.bbrc.2017.08.026","title":"Atorvastatin and lovastatin, but not pravastatin, increased cellular complex formation between PCSK9 and the LDL receptor in human hepatocyte-like C3A cells","year":2017,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Graduate Women – New South Wales; Institute of Infection and Immunity; North Carolina State University; University of South Florida; Grant Foundation","keywords":"PCSK9; LDL receptor; Atorvastatin; Pravastatin; Proprotein convertase; Lovastatin; Kexin; Hepatocyte; Statin; Chemistry; Familial hypercholesterolemia; Pharmacology; Endocrinology; Internal medicine; Cholesterol; Lipoprotein; Biology; Biochemistry; Medicine; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725745,0.0002948424,0.0005359286,0.0003586134,0.0004566101,0.0006396841,0.0002464736,0.0003681728,0.002804894],"category_scores_gemma":[0.0003048315,0.0002892011,0.0006919358,0.0003455313,0.000279167,0.0003071791,0.0003966134,0.0007058003,0.001010529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008331811,"about_ca_system_score_gemma":0.0004824568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005577973,"about_ca_topic_score_gemma":0.006036296,"domain_scores_codex":[0.9993812,0.0001282335,0.00008666177,0.0001114801,0.0001195106,0.0001730041],"domain_scores_gemma":[0.9997779,0.00005012706,0.0000237603,0.00004400862,0.00004780964,0.00005655444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001045012,0.0000642818,0.0002699236,0.00004927976,0.00002726737,0.00006372168,0.00005694732,0.00005890398,0.9972784,0.0001273431,0.0001803295,0.0007786612],"study_design_scores_gemma":[0.00008523144,0.0003001357,0.005208569,0.000004319923,0.00004363879,0.0001423212,0.00008866921,0.001196228,0.9901299,0.0000695144,0.002719227,0.00001230521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930372,0.001484045,0.002433278,0.0003474381,0.0001380344,0.00003197397,0.0009259672,0.0001090623,0.001492964],"genre_scores_gemma":[0.9919739,0.0005122058,0.001606345,0.00009072988,0.00002426114,0.00003376199,0.001297558,0.00003530534,0.004425823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005577973,"threshold_uncertainty_score":0.01109105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1217839379489913,"score_gpt":0.3829654673672274,"score_spread":0.2611815294182361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}