{"id":"W2743266104","doi":"10.1242/jcs.203885","title":"Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization","year":2017,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; Queen's University","funders":"Terry Fox Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children; Cancer Research Society","keywords":"Biology; Ubiquitin ligase; Internalization; Ubiquitin; Gene isoform; Cell biology; Ubiquitin-Protein Ligases; Differential (mechanical device); Genetics; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653304,0.0001802613,0.000211256,0.0001856905,0.0002611746,0.000605709,0.0001488141,0.0002956438,0.001058262],"category_scores_gemma":[0.0001546343,0.0001812787,0.0002640669,0.0001286505,0.0002204663,0.0003320511,0.0003657903,0.0003869636,0.0004334439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006677041,"about_ca_system_score_gemma":0.0001921373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005898159,"about_ca_topic_score_gemma":0.001430598,"domain_scores_codex":[0.9997455,0.00002677038,0.0000228535,0.00006479066,0.00004523808,0.00009466103],"domain_scores_gemma":[0.9999248,0.000009104308,0.00001883219,0.00000867714,0.00001303756,0.000025556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002261284,0.00001550585,0.0007607415,0.00001717648,0.000007615308,0.00007458247,0.00002092558,0.00003683209,0.9973207,0.0001724182,0.00004910147,0.001298258],"study_design_scores_gemma":[0.00002021145,0.0001049659,0.04633284,0.000007781046,0.00002511228,0.0005441721,0.0001117238,0.001612639,0.9482791,0.0001249927,0.002826057,0.0000103181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964314,0.001501999,0.0008577221,0.00004767397,0.00001484428,0.000005825163,0.000088786,0.00002998979,0.001021769],"genre_scores_gemma":[0.9971951,0.0004491498,0.0004800467,0.00002317234,0.000002817731,0.00000590425,0.0001442,0.00001136291,0.001688192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058262,"threshold_uncertainty_score":0.004844546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911458699636889,"score_gpt":0.3074303799897417,"score_spread":0.2683157929933728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}