{"id":"W2743329177","doi":"10.4049/jimmunol.1700495","title":"Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program","year":2017,"lang":"en","type":"review","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Immunological synapse; Effector; Immune system; Biology; Cell biology; Immunology; Lymphocyte; Integrin; Signal transduction; Lymphocyte function-associated antigen 1; CD8; Cell adhesion molecule; T cell; T-cell receptor; Receptor; Genetics; Intercellular Adhesion Molecule-1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003487065,0.0005953875,0.0008675816,0.001410755,0.0002624161,0.0008615625,0.0006180106,0.0008694221,0.003646524],"category_scores_gemma":[0.0003796167,0.0001935026,0.000274051,0.001134682,0.0003857456,0.001124432,0.0005246101,0.00125443,0.002579868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000503546,"about_ca_system_score_gemma":0.0006422008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004088808,"about_ca_topic_score_gemma":0.0008593177,"domain_scores_codex":[0.999886,0.000017012,0.00001471252,0.00002285131,0.00004611982,0.00001333225],"domain_scores_gemma":[0.9998646,0.00004756691,0.00001967102,0.000004750927,0.00004306873,0.00002035532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007668752,0.00005127624,0.0002369466,0.01021701,0.00006177432,0.0002114591,0.00005604515,0.0002147602,0.005021362,0.005442115,0.02742037,0.9509903],"study_design_scores_gemma":[0.0000111836,0.00007380266,0.0006740203,0.001245452,0.00004741884,0.0009938136,0.00004739768,0.00005586399,0.0007334949,0.00163106,0.9944751,0.00001129674],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002300164,0.9970515,0.000150739,0.0004358776,0.0004185628,0.000005395547,0.00001653806,0.000009271846,0.001682229],"genre_scores_gemma":[0.001211188,0.9966356,0.0002115464,0.000266352,0.0002841238,0.000008535261,0.00002466657,0.00000162056,0.001356356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003646524,"threshold_uncertainty_score":0.01219881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1450560177473265,"score_gpt":0.4381517889413575,"score_spread":0.293095771194031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}