{"id":"W2743399307","doi":"10.1371/journal.pone.0182995","title":"Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Endoplasmic reticulum; Unfolded protein response; Biology; ER retention; Mutation; Cell biology; Fatty liver; Golgi apparatus; Genetics; Gene; Mutant; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002969364,0.001495214,0.0006516401,0.001746412,0.0006607871,0.0007423466,0.0004985742,0.001597023,0.008959302],"category_scores_gemma":[0.000255664,0.0008599648,0.000802071,0.000677983,0.0006919503,0.0005873347,0.0006616432,0.001482725,0.002752701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624199,"about_ca_system_score_gemma":0.000297063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008153691,"about_ca_topic_score_gemma":0.001210963,"domain_scores_codex":[0.9995753,0.00003760322,0.00007366961,0.0001603094,0.00008688062,0.00006621857],"domain_scores_gemma":[0.9993134,0.00005945109,0.0002608666,0.00005093275,0.0000408129,0.0002745579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007928591,0.0002522056,0.0009571631,0.00007027535,0.00003808882,0.001355936,0.00006005062,0.0001132719,0.994354,0.0003031302,0.0002415435,0.001461493],"study_design_scores_gemma":[0.001529159,0.003225699,0.09684534,0.0001948661,0.0004522738,0.02916928,0.000713772,0.005262859,0.839579,0.00135057,0.02149723,0.0001797883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805449,0.001059533,0.005613948,0.0006266339,0.0002615115,0.000158261,0.006933037,0.001015998,0.00378618],"genre_scores_gemma":[0.9628428,0.001359093,0.004659236,0.0004843308,0.00009359384,0.0004387429,0.005967102,0.0005022658,0.02365292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008959302,"threshold_uncertainty_score":0.02997184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895593711602644,"score_gpt":0.2369322248552207,"score_spread":0.2179762877391942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}