{"id":"W2743484375","doi":"10.1161/hyp.60.suppl_1.a367","title":"Abstract 367: A Nox4 Inhibitor, GKT 137831, Decreases Aldosterone Synthesis, Adiposity and Vascular Contractility in a Murine Model of Diabetes.","year":2012,"lang":"en","type":"article","venue":"Hypertension","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"","keywords":"Endocrinology; Internal medicine; Aldosterone; Vascular smooth muscle; Diabetes mellitus; Mesenteric arteries; Adipocyte; NOX4; Medicine; Blood pressure; Contractility; Electrical impedance myography; Type 2 diabetes; Adipose tissue; Vasodilation; Artery; NADPH oxidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621645,0.0009214858,0.0009581475,0.0005061754,0.0002485337,0.0003329929,0.0004142547,0.0007139552,0.003813088],"category_scores_gemma":[0.0001058087,0.0003231727,0.0005448763,0.0003310242,0.000503773,0.0003948958,0.0002206956,0.001575281,0.0009764982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004571207,"about_ca_system_score_gemma":0.0007708641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247187,"about_ca_topic_score_gemma":0.001590359,"domain_scores_codex":[0.9997491,0.0000272482,0.00002674759,0.00004123579,0.00006543015,0.00009029318],"domain_scores_gemma":[0.9998454,0.00000841614,0.00004027246,0.000009249653,0.00001067739,0.0000859562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004157921,0.0006261573,0.0003517027,0.0002430513,0.00004292509,0.0001329691,0.00002332163,0.0001180424,0.9889409,0.0001903775,0.0005924038,0.004580332],"study_design_scores_gemma":[0.001459555,0.0110253,0.01056416,0.00005319984,0.0001542235,0.0007570284,0.000100983,0.00119008,0.9700233,0.000226813,0.004413563,0.00003183255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853955,0.004372893,0.002246085,0.001010149,0.0004182851,0.0000945643,0.002301892,0.0007151897,0.003445377],"genre_scores_gemma":[0.9800828,0.004181447,0.00345699,0.0005432246,0.00009312569,0.0001884946,0.002895988,0.00008704624,0.008470911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003813088,"threshold_uncertainty_score":0.01275605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03510401846173082,"score_gpt":0.2419594308291087,"score_spread":0.2068554123673779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}