{"id":"W2743569343","doi":"10.1200/jco.2014.32.15_suppl.2540","title":"Phase 1 first-in-human (FIH) study of nesvacumab (REGN910) a fully human and selective angiopoietin-2 (Ang2) monoclonal antibody (MAb): Results from hepatocellular carcinoma (HCC) cohort.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Nausea; Hepatocellular carcinoma; Adverse effect; Vomiting; Internal medicine; Sorafenib; Gastroenterology; Angiopoietin receptor; Oncology; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001039533,0.001319635,0.001296334,0.0002746099,0.0003322838,0.0006293851,0.0004794757,0.0007789179,0.003588133],"category_scores_gemma":[0.0005465614,0.0003930059,0.0005962041,0.0001764188,0.0005805179,0.0006378426,0.0003282561,0.002040827,0.0005914955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008386872,"about_ca_system_score_gemma":0.0009798206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000844088,"about_ca_topic_score_gemma":0.00234891,"domain_scores_codex":[0.9997979,0.00007497057,0.000007355525,0.00003504262,0.00002201532,0.00006273991],"domain_scores_gemma":[0.999593,0.00006594529,0.00006391283,0.00003413857,0.00002274101,0.0002203884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.535909,0.1224506,0.02011901,0.001064205,0.00190265,0.0009865855,0.0005881005,0.005513913,0.1281573,0.0005633209,0.01799058,0.1647547],"study_design_scores_gemma":[0.31514,0.6042205,0.04446398,0.00004815267,0.0007951573,0.001828466,0.0001072236,0.002446371,0.01875492,0.0005623487,0.01157137,0.00006151101],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932928,0.001272796,0.0005395545,0.0002311843,0.00005169693,0.001323233,0.001698994,0.0000665894,0.001523099],"genre_scores_gemma":[0.986296,0.0009646449,0.001754991,0.0006924936,0.0001073584,0.001353952,0.005080663,0.00003222977,0.003717747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003588133,"threshold_uncertainty_score":0.01200354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05289757525178797,"score_gpt":0.4142752304600787,"score_spread":0.3613776552082907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}