{"id":"W2743753720","doi":"10.1126/science.aan0218","title":"UBE2O remodels the proteome during terminal erythroid differentiation","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Biogen Idec; Biogen","keywords":"Reticulocyte; Cytosol; Proteome; Cell biology; Complement (music); Terminal (telecommunication); Globin; Chemistry; Erythroblast; Biology; Biochemistry; Gene; Messenger RNA; Phenotype; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290652,0.00006134104,0.00008753289,0.00004657313,0.001242327,0.00007840928,0.0002694953,0.00002705638,0.00007192615],"category_scores_gemma":[0.0001987642,0.00003608306,0.00003019176,0.00007867692,0.0007591696,0.0002423915,0.0001046225,0.0001182193,0.00007687804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003662727,"about_ca_system_score_gemma":0.00009972875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001003987,"about_ca_topic_score_gemma":0.000004490691,"domain_scores_codex":[0.9992436,0.00001323878,0.00008961379,0.000220849,0.000241294,0.0001913835],"domain_scores_gemma":[0.9991689,0.000009484073,0.00009044542,0.0005887387,0.00007823852,0.00006417737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000609261,0.0000265123,0.005629356,0.00002277424,0.000002642753,0.00001003122,0.0002537402,0.000003404457,0.9907286,0.0002297989,0.00003543871,0.002996734],"study_design_scores_gemma":[0.0003698379,0.00008802472,0.9365712,0.00003596428,0.000009542771,0.0001232033,0.00003890985,0.00100527,0.06081704,0.0005298172,0.0003552812,0.00005588341],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938111,0.0000146034,0.0001947954,0.00197357,0.0004516324,0.0002189545,7.989997e-7,0.00002765803,0.003306844],"genre_scores_gemma":[0.9967282,0.00001271523,0.000200747,0.000204552,0.0002209221,0.00001264805,8.420434e-7,0.000003807147,0.002615517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9309419,"threshold_uncertainty_score":0.9555103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02837716597438982,"score_gpt":0.3026190999820766,"score_spread":0.2742419340076868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}