{"id":"W2743753720","doi":"10.1126/science.aan0218","title":"UBE2O remodels the proteome during terminal erythroid differentiation","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Biogen Idec; Biogen","keywords":"Reticulocyte; Cytosol; Proteome; Cell biology; Complement (music); Terminal (telecommunication); Globin; Chemistry; Erythroblast; Biology; Biochemistry; Gene; Messenger RNA; Phenotype; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138967,0.0001534831,0.0001729267,0.0001849765,0.0002563929,0.0005602185,0.0001842093,0.0003350778,0.001188857],"category_scores_gemma":[0.0001441648,0.0001493323,0.0001359838,0.0001607106,0.0002816882,0.0003912969,0.0003614386,0.0007141686,0.0006477593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003825765,"about_ca_system_score_gemma":0.0001959217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003059486,"about_ca_topic_score_gemma":0.0006556176,"domain_scores_codex":[0.9999148,0.000008701018,0.000004783076,0.00001807553,0.00003244622,0.00002123572],"domain_scores_gemma":[0.9999079,0.000009983063,0.00002369324,0.000008108428,0.00001570845,0.00003459351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003911032,0.00001833302,0.00105607,0.00006005297,0.000006724674,0.0003975247,0.00007923349,0.00007575077,0.984951,0.001486221,0.001517495,0.009960595],"study_design_scores_gemma":[0.0000448271,0.0001928893,0.04478196,0.00004393718,0.00002727776,0.001844233,0.0003588874,0.001187234,0.8934171,0.001580602,0.0565048,0.00001625941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568821,0.01905414,0.008696857,0.003044043,0.0006507538,0.00003157976,0.0008733235,0.0003264023,0.01044092],"genre_scores_gemma":[0.9780853,0.005467201,0.002467387,0.0008062091,0.00009213029,0.00001606304,0.000557447,0.00009714865,0.01241113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188857,"threshold_uncertainty_score":0.00397706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02837716597438982,"score_gpt":0.3026190999820766,"score_spread":0.2742419340076868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}