{"id":"W2743803136","doi":"10.1016/j.bcp.2017.08.004","title":"Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1","year":2017,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; PROTEO; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Hydroxysteroid dehydrogenase; Steroid; Enzyme; Chemistry; Potency; Biochemistry; In vitro; Dehydrogenase; Mechanism of action; Benzamide; Mode of action; Pharmacology; Stereochemistry; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004058966,0.0004227289,0.0003055283,0.0002618466,0.000178614,0.0004793132,0.0006348309,0.0003355611,0.002848287],"category_scores_gemma":[0.0001773517,0.0002301207,0.0002326875,0.0001301122,0.0004261018,0.0005253607,0.0002409147,0.0008723061,0.0007214597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186863,"about_ca_system_score_gemma":0.0006010832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006800214,"about_ca_topic_score_gemma":0.0008271096,"domain_scores_codex":[0.9999022,0.00001526728,0.000005731819,0.00002282572,0.00002462857,0.00002922122],"domain_scores_gemma":[0.9999329,0.00001846329,0.00001363693,0.0000119487,0.0000119396,0.00001124764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003419772,0.00009526261,0.000538527,0.0001687698,0.00001832008,0.0002389176,0.00004492409,0.0007246431,0.9608251,0.00926381,0.0003305255,0.02740905],"study_design_scores_gemma":[0.00009041507,0.001219541,0.002741807,0.00001864117,0.00005793821,0.001648416,0.00008145925,0.002877307,0.9663081,0.002690924,0.02224586,0.00001971775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8150425,0.04748955,0.08843979,0.004604423,0.0003633363,0.0002272896,0.000961001,0.000799084,0.04207297],"genre_scores_gemma":[0.9617918,0.01875204,0.01028163,0.0005336893,0.0001023508,0.00004031121,0.0003691653,0.00003990873,0.008088955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002848287,"threshold_uncertainty_score":0.009528518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270269419235748,"score_gpt":0.3139333688755526,"score_spread":0.3012306746831951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}