{"id":"W2743803136","doi":"10.1016/j.bcp.2017.08.004","title":"Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1","year":2017,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; PROTEO; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Hydroxysteroid dehydrogenase; Steroid; Enzyme; Chemistry; Potency; Biochemistry; In vitro; Dehydrogenase; Mechanism of action; Benzamide; Mode of action; Pharmacology; Stereochemistry; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129441,0.0001317463,0.0002322403,0.00003160027,0.00007821605,0.000004627665,0.0002166043,0.0002476093,0.000006012834],"category_scores_gemma":[0.00006916081,0.00009837353,0.00007870844,0.00004634806,0.0005081872,0.00000629812,0.000219862,0.0001441282,8.62245e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001228546,"about_ca_system_score_gemma":0.00006875715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005996559,"about_ca_topic_score_gemma":0.00000319787,"domain_scores_codex":[0.9991792,0.00009983596,0.0002425194,0.0002330165,0.00009656214,0.0001488111],"domain_scores_gemma":[0.9992192,0.00003120946,0.0002964086,0.0002737881,0.0001127389,0.00006669504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007409567,0.0001719885,0.0007820606,0.0001056325,0.0001795479,0.000001503367,0.0001383069,0.00001064305,0.9958041,0.000007974107,0.001677951,0.0003793039],"study_design_scores_gemma":[0.0009858754,0.000579606,0.000366407,0.00001521655,0.0000973939,0.00001464273,0.00001094083,0.0002502616,0.9969381,0.00002296626,0.0006280767,0.00009050839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966072,0.002689567,0.00002916864,0.0001034489,0.0002300252,0.0002230138,0.000011028,0.0000039287,0.000102645],"genre_scores_gemma":[0.9991461,0.0005463971,0.00007210539,0.00004061167,0.0001267753,0.00001019627,0.00001579051,0.00001233035,0.00002970171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538917,"threshold_uncertainty_score":0.4011556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270269419235748,"score_gpt":0.3139333688755526,"score_spread":0.3012306746831951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}