{"id":"W2743888064","doi":"10.1002/cmdc.201700414","title":"Development of Substrate‐Derived Sirtuin Inhibitors with Potential Anticancer Activity","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Deutsche Forschungsgemeinschaft","keywords":"Sirtuin; SIRT2; Acetylation; Lysine; Regulator; Sirtuin 1; Cell biology; Cytosol; Cell growth; Biology; Biochemistry; P300-CBP Transcription Factors; Chemistry; Amino acid; Downregulation and upregulation; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628783,0.0004168516,0.0003049416,0.000285189,0.000105747,0.0001861858,0.0002679014,0.0002619682,0.001413623],"category_scores_gemma":[0.00008320981,0.0001181177,0.000277175,0.0001791772,0.0001167272,0.0001709926,0.0001202886,0.0004837965,0.0004190659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207172,"about_ca_system_score_gemma":0.0001826065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000299187,"about_ca_topic_score_gemma":0.00105686,"domain_scores_codex":[0.9999506,0.00001146594,0.000003790741,0.000009587123,0.00001213633,0.00001228652],"domain_scores_gemma":[0.9999692,0.000004014504,0.000008546188,0.000003796893,0.000006529739,0.000007843755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003138658,0.000164051,0.0002425816,0.0001892278,0.0000347199,0.0001412639,0.00001969546,0.0003804603,0.9744388,0.0005508648,0.000278017,0.0232464],"study_design_scores_gemma":[0.0002182146,0.002649599,0.002053834,0.00002268478,0.0001082068,0.0006763032,0.00002105215,0.00141062,0.9717277,0.0001374414,0.02096049,0.00001387304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9375846,0.03180024,0.01850699,0.000586498,0.0001649471,0.0003286161,0.000984295,0.0003497533,0.009694098],"genre_scores_gemma":[0.9720086,0.01294822,0.0104445,0.0001875095,0.00003953336,0.00006304606,0.001247387,0.00002484055,0.003036459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413623,"threshold_uncertainty_score":0.004729033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500269046946938,"score_gpt":0.2870635258010689,"score_spread":0.2620608353315995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}