{"id":"W2743888064","doi":"10.1002/cmdc.201700414","title":"Development of Substrate‐Derived Sirtuin Inhibitors with Potential Anticancer Activity","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Deutsche Forschungsgemeinschaft","keywords":"Sirtuin; SIRT2; Acetylation; Lysine; Regulator; Sirtuin 1; Cell biology; Cytosol; Cell growth; Biology; Biochemistry; P300-CBP Transcription Factors; Chemistry; Amino acid; Downregulation and upregulation; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895591,0.0001970727,0.0004391334,0.00005320073,0.0002186712,0.00002235145,0.0001662588,0.0001219647,0.0001225004],"category_scores_gemma":[0.00006971833,0.000132527,0.0000716939,0.00006051041,0.0004261582,0.0000949626,0.00006590062,0.0002351983,0.000009159961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006325845,"about_ca_system_score_gemma":0.0003560836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002858754,"about_ca_topic_score_gemma":0.00001999393,"domain_scores_codex":[0.99872,0.000007781436,0.0002532013,0.0002856983,0.0004479564,0.0002852942],"domain_scores_gemma":[0.9988029,0.00001503126,0.0002564903,0.0005751939,0.0001533349,0.0001970682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005986326,0.0002388379,0.008102645,0.0001720161,0.0001810391,0.0001029042,0.0004189376,0.000001175342,0.9714506,0.0000128133,0.0002845753,0.01843582],"study_design_scores_gemma":[0.002623659,0.0001321385,0.1386356,0.0002592848,0.000091841,0.00003677572,0.0002044689,0.00005079776,0.8572673,0.000004969707,0.0005560331,0.000137173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938936,0.00007714154,0.0003609594,0.0009484075,0.0002120065,0.0002406694,0.000001509167,0.00003235562,0.004233326],"genre_scores_gemma":[0.9946122,0.00002888111,0.004350221,0.00007514216,0.0003600488,0.00001544089,0.00000911479,0.00002672055,0.0005222455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.130533,"threshold_uncertainty_score":0.5404294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500269046946938,"score_gpt":0.2870635258010689,"score_spread":0.2620608353315995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}