{"id":"W2743915325","doi":"10.1101/gad.298463.117","title":"Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Cancer Research Institute; Medical Research Council; Medical Research Council Canada; Cancer Research UK; National Institutes of Health","keywords":"Biology; Cancer research; Mutant; Adenocarcinoma; KRAS; Lung cancer; Genotype; Loss of heterozygosity; Targeted therapy; Wild type; Lung; Phenotype; Mutation; Cancer; Genetics; Pathology; Gene; Internal medicine; Allele; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004812105,0.0003797591,0.0004278979,0.0002225693,0.0007472173,0.0001519817,0.0001836432,0.0001069382,0.0001416202],"category_scores_gemma":[0.0001209767,0.0003269777,0.00007502743,0.0002595462,0.000121094,0.0001148949,0.000121479,0.0002507835,0.0001482336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004757494,"about_ca_system_score_gemma":0.001040232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000112292,"about_ca_topic_score_gemma":0.0005136681,"domain_scores_codex":[0.9975898,0.00009839687,0.0004249217,0.0006771193,0.0006523212,0.0005574832],"domain_scores_gemma":[0.9980333,0.00005734027,0.0002331361,0.0009094768,0.0004050427,0.0003616315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004031254,0.0003939014,0.01849727,0.0001177342,0.0005771692,0.00422541,0.01260504,0.0007268341,0.6919101,0.00008830088,0.003537972,0.263289],"study_design_scores_gemma":[0.002808239,0.0003077515,0.6337032,0.0003287898,0.00005491497,0.0001833356,0.0003190996,0.0001276581,0.3019172,0.00002200738,0.05960976,0.0006180889],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764175,0.001491836,0.01858294,0.0009455843,0.0002520139,0.001280524,0.0000732227,0.0001365739,0.00081974],"genre_scores_gemma":[0.961217,0.0001521278,0.03650577,0.0003844775,0.0001313555,0.0001583027,0.0002536835,0.00009609952,0.001101114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6152059,"threshold_uncertainty_score":0.9999182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322927259219367,"score_gpt":0.2660414263603189,"score_spread":0.2428121537681252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}