{"id":"W2744121986","doi":"10.1155/2017/1503960","title":"Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Immunology Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; RIPK1; Cell biology; Programmed cell death; Apoptosis; Intracellular; Caspase; Biology; Caspase 8; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001414029,0.0001101994,0.0002280022,0.000227762,0.0002840723,0.00008921382,0.000406494,0.000292158,0.0000256844],"category_scores_gemma":[0.0002371226,0.00009176551,0.00008167301,0.00005446777,0.0002737333,0.00001676603,0.0002156006,0.0004303601,0.000003979432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002548268,"about_ca_system_score_gemma":0.0001042038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007189022,"about_ca_topic_score_gemma":0.00002196395,"domain_scores_codex":[0.9987134,0.0002180259,0.0003330944,0.0002006623,0.0002063912,0.000328434],"domain_scores_gemma":[0.9990177,0.00003831156,0.000235475,0.0003855602,0.0002557741,0.00006716537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003215216,0.00006943546,0.0005146762,0.000009331466,0.00007132549,0.00001407122,0.00009099865,0.000006395329,0.9803917,0.00009881963,0.00009890164,0.01831276],"study_design_scores_gemma":[0.001213901,0.0007846835,0.009782585,0.00003500571,0.000009454662,0.00007457995,0.0001704432,0.00003469991,0.9844404,0.0004823131,0.002879721,0.00009223222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997012,0.00161115,0.00006170564,0.0006953854,0.0002876078,0.0001191302,0.000002552118,0.000001472488,0.0002090392],"genre_scores_gemma":[0.9954036,0.003294464,0.0004347401,0.00001057975,0.0002456245,0.000003840534,0.000002595894,0.00001598706,0.0005885017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01822053,"threshold_uncertainty_score":0.3742089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335602878072916,"score_gpt":0.3189719689247714,"score_spread":0.2854116811174798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}