{"id":"W2744121986","doi":"10.1155/2017/1503960","title":"Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Immunology Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; RIPK1; Cell biology; Programmed cell death; Apoptosis; Intracellular; Caspase; Biology; Caspase 8; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848286,0.0001554941,0.0002098053,0.0001624724,0.0001377874,0.000355373,0.000114107,0.0001805138,0.0009840609],"category_scores_gemma":[0.0001639814,0.00008872689,0.0001813484,0.0001306361,0.0001982424,0.0002732166,0.0001954541,0.0004388207,0.0002847082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984327,"about_ca_system_score_gemma":0.0001766799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002074331,"about_ca_topic_score_gemma":0.0002381417,"domain_scores_codex":[0.9998313,0.00004896069,0.00001802472,0.00002456565,0.00003435999,0.00004278972],"domain_scores_gemma":[0.9999068,0.00001249892,0.00003422518,0.000007830962,0.00001631805,0.00002237596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007086185,0.00005837921,0.000381125,0.00004963929,0.000006422751,0.00008053358,0.00002431705,0.000103554,0.9964641,0.000148954,0.00007575068,0.001898721],"study_design_scores_gemma":[0.0001047098,0.0005177491,0.009342261,0.0000139054,0.00002504836,0.0003433795,0.00006738157,0.001970628,0.9851124,0.0002305306,0.002262843,0.000009191783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916013,0.003792684,0.002291783,0.000152856,0.00004059251,0.00002409434,0.0002230573,0.00005638421,0.001817155],"genre_scores_gemma":[0.9970914,0.0009999113,0.0007543563,0.00005184674,0.00001061914,0.00002042589,0.0001452192,0.000007154977,0.0009190611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009840609,"threshold_uncertainty_score":0.003292024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0335602878072916,"score_gpt":0.3189719689247714,"score_spread":0.2854116811174798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}