{"id":"W2744157110","doi":"10.1016/j.jogc.2017.05.015","title":"Cell-Free DNA–Based Non-invasive Prenatal Screening for Common Aneuploidies in a Canadian Province: A Cost-Effectiveness Analysis","year":2017,"lang":"en","type":"article","venue":"Journal of Obstetrics and Gynaecology Canada","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; University of Alberta Hospital; Alberta Hospital Edmonton; Université Laval; Université de Montréal; University of British Columbia; University of Ottawa","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"Medicine; Cell-free fetal DNA; Prenatal screening; Trisomy; Cost effectiveness; Cohort; Obstetrics; Cost-effectiveness analysis; Gynecology; Prenatal diagnosis; Pregnancy; Fetus; Internal medicine; Risk analysis (engineering)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003172027,0.001353763,0.001884653,0.001941211,0.001080211,0.001770857,0.001961511,0.001208586,0.003535727],"category_scores_gemma":[0.009642647,0.0006801751,0.003605781,0.003945701,0.001063711,0.0005886607,0.001089995,0.001524853,0.0001067812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.09657175,"about_ca_system_score_gemma":0.0892946,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9732579,"about_ca_topic_score_gemma":0.9763089,"domain_scores_codex":[0.9958115,0.001370889,0.0002142146,0.0002701467,0.001338244,0.0009950376],"domain_scores_gemma":[0.9958872,0.001736957,0.0004871942,0.00007483501,0.0009888054,0.0008249829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0842598,0.007483467,0.4473886,0.0178915,0.02394495,0.002232585,0.001449771,0.1227018,0.003933393,0.006081162,0.01320344,0.2694296],"study_design_scores_gemma":[0.01903192,0.02457151,0.7765464,0.003217739,0.0427903,0.001312757,0.004217926,0.1161505,0.001281505,0.001462887,0.008959047,0.0004575076],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648224,0.01662918,0.001545948,0.002126439,0.00009912845,0.002335694,0.006762407,0.00004737059,0.005631425],"genre_scores_gemma":[0.9889377,0.006009504,0.002074243,0.0004543472,0.00002095274,0.0002413809,0.001451113,0.000006980718,0.0008036161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09657175,"threshold_uncertainty_score":0.7006804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976597446330733,"score_gpt":0.271241179816521,"score_spread":0.2514752053532136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}