{"id":"W2744160381","doi":"10.1016/s0140-6736(17)31442-3","title":"Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":397,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Medical Research Council; Cancer Research UK","keywords":"Temozolomide; Medicine; Interim analysis; Internal medicine; Oncology; Glioma; Hazard ratio; Oligodendroglial Tumor; Radiation therapy; Anaplastic astrocytoma; Dacarbazine; Clinical endpoint; Chemotherapy; Clinical trial; Oligodendroglioma; Astrocytoma; Confidence interval; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003606251,0.001422453,0.003082955,0.0002845668,0.0004555263,0.001267705,0.000776778,0.001659678,0.005904527],"category_scores_gemma":[0.003179183,0.0004070032,0.002885779,0.0003551881,0.0009603972,0.001329329,0.0005026559,0.003021471,0.001188133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009078337,"about_ca_system_score_gemma":0.001595601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366124,"about_ca_topic_score_gemma":0.005085894,"domain_scores_codex":[0.9986585,0.0009156434,0.00005486645,0.0001333984,0.00007794362,0.0001595651],"domain_scores_gemma":[0.9979331,0.0007276299,0.0003562369,0.0002554638,0.0001301036,0.0005973874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.966795,0.002661175,0.001438929,0.0006788658,0.002337017,0.00006695215,0.00007846153,0.0007601327,0.002899584,0.0002942999,0.005190256,0.01679931],"study_design_scores_gemma":[0.914203,0.06753099,0.01027741,0.00007347255,0.002207719,0.0001093764,0.00006865495,0.0005096549,0.0005848423,0.0007823481,0.003617191,0.00003534462],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561732,0.009376639,0.002000451,0.002916543,0.001651608,0.003364165,0.01343068,0.0002991721,0.01078749],"genre_scores_gemma":[0.949082,0.003394848,0.00324481,0.004324163,0.0005951565,0.004285826,0.02341393,0.0001541385,0.01150528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005904527,"threshold_uncertainty_score":0.01975262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1218691704185722,"score_gpt":0.411055170632716,"score_spread":0.2891860002141439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}