{"id":"W2744160381","doi":"10.1016/s0140-6736(17)31442-3","title":"Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":397,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Medical Research Council; Cancer Research UK","keywords":"Temozolomide; Medicine; Interim analysis; Internal medicine; Oncology; Glioma; Hazard ratio; Oligodendroglial Tumor; Radiation therapy; Anaplastic astrocytoma; Dacarbazine; Clinical endpoint; Chemotherapy; Clinical trial; Oligodendroglioma; Astrocytoma; Confidence interval; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008195558,0.0003973822,0.001596251,0.00005676118,0.000426353,0.0002206091,0.0006830249,0.00004864876,0.00001196072],"category_scores_gemma":[0.0003680831,0.0001714208,0.00009596971,0.00007689131,0.0002313518,0.0001002146,0.0002321449,0.0001394245,0.000004486159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373044,"about_ca_system_score_gemma":0.0001186085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003339396,"about_ca_topic_score_gemma":0.003307398,"domain_scores_codex":[0.9978843,0.0002368805,0.0006798237,0.0005826975,0.0002666347,0.0003496792],"domain_scores_gemma":[0.9962255,0.00122076,0.0006546285,0.001658267,0.0001138001,0.0001270958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.920735,0.02982304,0.01022853,0.0000253392,0.003903702,0.0003222253,0.01064907,0.000002417022,0.001584771,0.000007050316,0.003341669,0.01937719],"study_design_scores_gemma":[0.8949535,0.07820062,0.01811814,0.0002863843,0.002180614,0.00002108674,0.003338664,0.0005374966,0.001771497,0.00001384459,0.0003909019,0.0001871734],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811704,0.0002486859,0.00003682316,0.00136924,0.000327388,0.01602999,0.0006700256,0.00002274686,0.0001246905],"genre_scores_gemma":[0.9967601,0.0000752997,0.00005561074,0.0000641529,0.0004938549,0.002331237,0.0001434221,0.00003601667,0.00004026178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04837758,"threshold_uncertainty_score":0.6990339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1218691704185722,"score_gpt":0.411055170632716,"score_spread":0.2891860002141439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}