{"id":"W2744195134","doi":"10.1016/j.neubiorev.2017.08.002","title":"Transgenerational effects of early environmental insults on aging and disease incidence","year":2017,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Birth, Development, and Health","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transgenerational epigenetics; Disease; Epigenetics; Inheritance (genetic algorithm); Malnutrition; Psychological intervention; Mechanism (biology); Developmental psychology; Psychology; Medicine; Biology; Psychiatry; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004544756,0.0004548866,0.0016373,0.0001856608,0.0002861567,0.00005903999,0.0003258929,0.0001376672,0.00001302877],"category_scores_gemma":[0.0002953727,0.0003249348,0.0003203787,0.0001426224,0.0004423198,0.0001778878,0.00008380153,0.0004452893,0.00002994673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001036699,"about_ca_system_score_gemma":0.0007132653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000137989,"about_ca_topic_score_gemma":0.000001920986,"domain_scores_codex":[0.9973071,0.0001472651,0.0008262938,0.0007872376,0.0005847715,0.0003473428],"domain_scores_gemma":[0.9979875,0.000007434231,0.0007026745,0.0006388551,0.00001539817,0.0006481113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001019553,0.0001786978,0.002069937,0.01135395,1.799606e-7,0.0000734814,0.00003843295,6.69072e-9,0.0002769914,0.0001375275,0.00006065006,0.9858],"study_design_scores_gemma":[0.0002968976,0.0005259343,0.04472907,0.02213307,0.0004723843,0.00004443735,6.043344e-7,0.000001207062,0.000008602161,0.00001820699,0.9314815,0.0002881059],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008368013,0.9886203,0.00001000385,0.00001168123,0.0004309357,0.002448925,0.00006350371,0.00001590683,0.00003072212],"genre_scores_gemma":[0.005123301,0.9937909,0.0001615955,0.0005326323,0.0000936005,0.0001764416,0.00004075794,0.00003077062,0.0000500625],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9855118,"threshold_uncertainty_score":0.9999202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1818003980996407,"score_gpt":0.4288717502206951,"score_spread":0.2470713521210544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}