{"id":"W2744199900","doi":"10.1161/circgenetics.116.001631","title":"<i>Lamin A/C</i> -Related Cardiac Disease","year":2017,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hendrix Genetics (Canada)","funders":"","keywords":"LMNA; Lamin; Cardiomyopathy; Missense mutation; Heart failure; Proband; Dilated cardiomyopathy; Biology; Internal medicine; Genetics; Pathology; Medicine; Phenotype; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002405713,0.0001817035,0.0002087935,0.00003444499,0.0004551977,0.0001227333,0.0002681003,0.0001769436,0.00001960445],"category_scores_gemma":[0.0001061709,0.000196177,0.0007046186,0.00004023433,0.0001167176,0.000008524101,0.0001317008,0.00008667774,0.00005368606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001785095,"about_ca_system_score_gemma":0.00005585326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000729465,"about_ca_topic_score_gemma":0.000001766843,"domain_scores_codex":[0.9987451,0.00007976755,0.0001936302,0.0004616581,0.0002982552,0.0002215275],"domain_scores_gemma":[0.9976937,0.000002942497,0.0001051247,0.001915914,0.0001273865,0.0001549025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002248945,0.0001226125,0.3503155,0.0001652411,0.007464048,0.00006842247,0.0001743625,0.06351707,0.2906964,0.00235171,0.009225084,0.2756747],"study_design_scores_gemma":[0.0006271455,0.00002620408,0.6615816,0.000008917809,0.0003863032,0.000009591888,0.00001331261,0.0006004896,0.003787235,0.0003717196,0.3322202,0.00036723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716079,0.01593267,0.0055765,0.0001327992,0.001925249,0.0004194076,0.00003365879,0.00004523901,0.004326623],"genre_scores_gemma":[0.9975175,0.0006191705,0.0002956694,0.000058219,0.0007133726,0.00001364978,0.0002112901,0.00004756393,0.0005235418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3229951,"threshold_uncertainty_score":0.7999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009072498050041471,"score_gpt":0.2185671284692108,"score_spread":0.2094946304191693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}