{"id":"W2744273464","doi":"10.1158/1535-7163.mct-17-0259","title":"Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor–Chromatin Interactions","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Enzalutamide; Androgen receptor; Prostate cancer; LNCaP; Chemistry; Chromatin; DNA-binding domain; Cancer research; Small molecule; Transcription factor; Pharmacology; Mechanism of action; Cancer; Biology; DNA; Biochemistry; Genetics; In vitro; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170397,0.0003830837,0.0003812314,0.0004443062,0.0001543928,0.0003886153,0.0002558071,0.0001807521,0.002572355],"category_scores_gemma":[0.000104765,0.0001271519,0.0003181888,0.0002392368,0.0002358312,0.0001475437,0.0002322834,0.0007187945,0.0006576625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000382015,"about_ca_system_score_gemma":0.0002733649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007253329,"about_ca_topic_score_gemma":0.00192112,"domain_scores_codex":[0.9998845,0.00002272042,0.000006605092,0.00001997294,0.00003986565,0.00002639637],"domain_scores_gemma":[0.9999387,0.00001415131,0.00001634121,0.00000956686,0.00001014351,0.00001112348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001769428,0.0004410669,0.0004660896,0.0003421516,0.00004395168,0.0001334801,0.0000371985,0.001259324,0.9590415,0.001467454,0.001336446,0.0352545],"study_design_scores_gemma":[0.0002317195,0.003362566,0.004123862,0.00003193445,0.00006952207,0.0006393375,0.00002646593,0.003696243,0.9532978,0.0002769994,0.03422091,0.00002258363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.920803,0.03373013,0.02094904,0.001005013,0.0002987296,0.0006215298,0.001471093,0.001083373,0.02003812],"genre_scores_gemma":[0.9782898,0.008909798,0.005472744,0.0002409167,0.00003548107,0.0001542486,0.0007347963,0.00004428267,0.006117994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572355,"threshold_uncertainty_score":0.008605421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388678794563423,"score_gpt":0.327327484174485,"score_spread":0.2834406962288508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}